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首页> 外文期刊>Journal of chemical neuroanatomy >Cell proliferation and apoptosis in the olfactory epithelium of the shark Scyliorhinus canicula.
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Cell proliferation and apoptosis in the olfactory epithelium of the shark Scyliorhinus canicula.

机译：鲨鱼Scyliorhinus canicula的嗅上皮中的细胞增殖和凋亡。

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摘要

To date, no study has been published on cell renewal in the olfactory epithelium of Chondrichthyes. Our work aimed at detecting proliferating cells (by Proliferating Cell Nuclear Antigen - PCNA immunohistochemistry) and apoptotic cells (by terminal uridine deoxynucleotidyl transferase nick end labeling method) in the olfactory epithelium of the shark Scyliorhinus canicula. PCNA immunoreactivity and mitotic figures were localized almost exclusively at the basal and apical thirds of the epithelial thickness. Double immunofluorescence for PCNA and OMP (a marker of mature olfactory neurons) showed that PCNA immunoreactivity is lacking in mature olfactory neurons, with the exception of crypt neurons. Crypt neurons, a cell type peculiar to fish, often showed PCNA immunoreactivity in the nucleus and may be involved in repair processes. The role of PCNA in mature crypt neurons requires further investigation to be clarified. Apoptosis was observed in sensory neurons and in basal cells. Our data highlight the presence of cell proliferation at different levels within the epithelium and the occurrence of apoptosis in both mature and proliferating cells.
机译：迄今为止，还没有发表关于软骨软骨动物嗅上皮细胞更新的研究。我们的工作旨在检测鲨鱼Scyliorhinus canicula嗅上皮中的增殖细胞（通过Proliferating Cell Nuclear Antigen-PCNA免疫组织化学）和凋亡细胞（通过末端尿苷脱氧核苷酸转移酶缺口末端标记法）。 PCNA免疫反应性和有丝分裂图几乎完全位于上皮厚度的基部和根部三分之二处。 PCNA和OMP（成熟嗅觉神经元的标志物）的双重免疫荧光显示，除了隐窝神经元以外，成熟嗅觉神经元缺乏PCNA免疫反应性。隐性神经元是鱼类特有的细胞类型，通常在细胞核中显示PCNA免疫反应性，并可能参与修复过程。 PCNA在成熟隐窝神经元中的作用有待进一步研究。在感觉神经元和基底细胞中观察到凋亡。我们的数据强调了上皮细胞内不同水平细胞增殖的存在以及成熟细胞和增殖细胞中细胞凋亡的发生。

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