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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast-enhanced ultrasound: An animal study
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Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast-enhanced ultrasound: An animal study

机译：通过对比造影超声检查肝实质灌注评估肝脏纤维化：一项动物研究

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Purpose:: To investigate the value of assessing the hepatic parenchymal perfusion in contrast-enhanced ultrasound (CEUS) for evaluating liver fibrosis, using an animal model. Methods:: Seventy Sprague-Dawley rats were divided into experimental (n = 35) and control (n = 35) groups. In the experimental group, liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride. CEUS of the liver was performed at a 2-week interval for 14 weeks. Signal intensity of liver parenchyma was analyzed with time-intensity curves. Histologic examination of liver specimens of the animals was performed to assess the fibrosis stage. Results:: The peak signal intensity of hepatic parenchymal perfusion in stage 2-3 fibrosis was significantly lower than that in stage 0-1. The time to peak intensity of hepatic parenchymal perfusion was significantly longer in the experimental group than the control group, and in the stage 3 fibrosis than in stages 0-2 fibrosis. Using time to peak intensity of hepatic parenchymal perfusion to distinguish stage 3 fibrosis and stages 0-2 fibrosis, the optimum cutoff was 75,000 milliseconds with the sensitivity and specificity of 67% and 78%, respectively. Conclusions:: This animal study showed that CEUS has the potential to be a complementary imaging tool in the evaluation of liver fibrosis.
机译：目的：：利用动物模型，探讨在超声造影（CEUS）中评估肝实质灌注对评估肝纤维化的价值。方法：将70只Sprague-Dawley大鼠分为实验组（n = 35）和对照组（n = 35）。在实验组中，通过腹膜内注射四氯化碳诱导肝纤维化。肝CEUS以2周为间隔进行14周。用时间强度曲线分析肝实质的信号强度。进行动物肝标本的组织学检查以评估纤维化阶段。结果：在2-3期纤维化中，肝实质灌注的峰值信号强度明显低于0-1期。实验组肝实质灌注达到峰值强度的时间明显长于对照组，并且在3期纤维化中比在0-2期纤维化中。使用达到肝实质灌注峰值强度的时间来区分3期纤维化和0-2期纤维化，最佳截止时间为75,000毫秒，敏感性和特异性分别为67％和78％。结论：这项动物研究表明，CEUS有潜力作为评估肝纤维化的辅助影像工具。

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