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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Are increased carotid artery pulsatility and resistance indexes early signs of vascular abnormalities in young obese males?
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Are increased carotid artery pulsatility and resistance indexes early signs of vascular abnormalities in young obese males?

机译：年轻肥胖男性的颈动脉搏动性和阻力增加是否是血管异常的早期征兆？

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摘要

Purpose: To provide insight into the factors by which obesity in itself may directly lead to early arterial damage, we aimed to determine early sonographic markers of obesity-related vascular dysfunction in young obese males. Methods: Thirty-five young obese males and 23 age-matched healthy male volunteers were recruited into the study. Common carotid artery pulsatility index and resistance index were calculated from blood flow velocities curves obtained by pulsed Doppler ultrasonography. Results: The mean pulsatility index, resistance index, body mass index, waist circumference, systolic and diastolic blood pressure, homeostasis model assessment for insulin resistance, plasma fasting glucose, insulin, C-peptide, triglycerides, low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein were statistically higher in obese subjects than in healthy controls. Conclusions: Our results suggest that depressed vessel compliance and increased vascular resistance are features of young, obese, normotensive subjects independently of and in addition to cardiovascular risk factors. As changes in arterial wall properties may be incipient in young obese subjects, future studies will be required to demonstrate whether early intervention such as diet and exercise in this population can improve vascular functions.
机译：目的：为了深入了解肥胖本身可直接导致早期动脉损伤的因素，我们旨在确定年轻肥胖男性中与肥胖相关的血管功能障碍的早期超声检查标志。方法：招募了35名年轻的肥胖男性和23名年龄相匹配的健康男性志愿者作为研究对象。从通过脉冲多普勒超声获得的血流速度曲线计算颈总动脉搏动指数和阻力指数。结果：平均搏动指数，抵抗指数，体重指数，腰围，收缩压和舒张压，胰岛素抵抗的稳态模型评估，血浆空腹血糖，胰岛素，C肽，甘油三酸酯，低密度脂蛋白胆固醇和高肥胖受试者的C敏感性C反应蛋白在统计学上高于健康对照组。结论：我们的研究结果表明，与心血管疾病危险因素无关，除了心血管危险因素外，抑郁的血管顺应性和血管阻力增加是年轻，肥胖，血压正常人群的特征。由于年轻肥胖受试者的动脉壁特性可能开始改变，因此需要进一步的研究来证明该人群的早期干预（例如饮食和锻炼）是否可以改善血管功能。

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