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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Effect of metformin treatment on endometrial vascular indices in anovulatory obese/overweight women with polycystic ovarian syndrome using three-dimensional power doppler ultrasonography
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Effect of metformin treatment on endometrial vascular indices in anovulatory obese/overweight women with polycystic ovarian syndrome using three-dimensional power doppler ultrasonography

机译：二甲双胍对三维功率多普勒超声检查对多囊卵巢综合征无肥胖/超重无排卵肥胖妇女子宫内膜血管指数的影响

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Purpose: Metformin has been shown to be an effective treatment for anovulatory polycystic ovary syndrome (PCOS) patients in terms of menstrual cyclicity, ovulation, and pregnancy, as well as reduction of early miscarriage rate. The aim of the study is to assess the effect of metformin on the endometrial vascular indices in anovulatory obese PCOS women using three-dimensional power Doppler sonography (3DPDUS). Methods: A prospective study was set to determine the beneficial effects of metformin on PCOS patients. Fifty anovulatory obese PCOS patients were compared with another 50 healthy volunteers who were age- and body mass index-matched (control group). PCOS patients were treated with metformin (Glucophage; MerckSerono) 850 mg 3 times a day for 6 months. Assessment of the endometrial thickness and volume, uterine Doppler indices, and Doppler vascular indices of the endometrium and subendometrium in the periovulatory and midluteal phases were performed with 3DPDUS. Results: There was a significant increase in the endometrial thickness, endometrial volume, and endometrial and subendometrial vascularity indices (vascularization index, flow index, vascularization flow index) after 6 months of metformin treatment in PCOS women, whereas there was no change in the resistance index and the pulsatility index of the uterine artery in both periovulatory and midluteal phases. Conclusions: Metformin, owing to its metabolic, endocrine, vascular, and anti-inflammatory effects, improves markers of endometrial receptivity.
机译：目的：从月经周期，排卵和妊娠以及减少早期流产的角度来看，二甲双胍已被证明是对无排卵性多囊卵巢综合症（PCOS）患者的有效治疗方法。这项研究的目的是使用三维能量多普勒超声（3DPDUS）评估二甲双胍对无排卵肥胖PCOS妇女子宫内膜血管指数的影响。方法：一项前瞻性研究旨在确定二甲双胍对PCOS患者的有益作用。将五十名无排卵肥胖PCOS患者与年龄和体重指数匹配的另外50名健康志愿者（对照组）进行比较。 PCOS患者每天3次接受850 mg二甲双胍（Glucophage; MerckSerono）治疗，持续6个月。使用3DPDUS评估了排卵周和中黄体期子宫内膜和子宫内膜的子宫内膜厚度和体积，子宫多普勒指数和多普勒血管指数。结果：PCOS妇女接受二甲双胍治疗6个月后，子宫内膜厚度，子宫内膜体积以及子宫内膜和子宫内膜下的血管指数（血管化指数，血流指数，血管化血流指数）显着增加，而抵抗力没有变化排卵期和黄体中期的子宫动脉指数和子宫动脉搏动指数。结论：二甲双胍由于其代谢，内分泌，血管和抗炎作用，可改善子宫内膜的接受性标志物。

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