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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects
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Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects

机译：主动脉间隔角度减小可能会导致健康受试者的左心室舒张功能障碍

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Background: Left ventricular (LV) diastolic dysfunction is often observed in healthy older subjects without structural heart disease, although its exact mechanisms have not been established. A decrease in the aorto-septal angle (ASA), an alteration of LV shape due to aortic elongation, is also frequently seen in elderly subjects. The objective of this study was to evaluate whether it can contribute to LV diastolic dysfunction in healthy subjects. Methods: Echocardiography was performed in 77 healthy subjects (42 men, mean age 43.2±13.8 years) to measure the ASA, early diastolic transmitral flow velocity (E), isovolumic relaxation time (IRT), and early diastolic mitral annular velocity (e'). The LV peak early diastolic longitudinal strain rate (GSRE) was measured using a two-dimensional speckle tracking imaging technique. Results: ASA was significantly correlated with E (r=0.54, p0.001), IRT (r=-0.41, p0.001), e' (r=0.57, p0.001), and GSRE (r=0.63, p0.001) and shown by stepwise multivariate analysis to be the strongest independent determinant of E, IRT, and GSRE, and one of the independent determinants of e'. Conclusions: The alteration of LV shape associated with reduced ASA may be one of the causes of LV diastolic dysfunction independently of age in otherwise healthy subjects.
机译：背景：尽管没有确切的机制，但在没有结构性心脏病的健康老年患者中经常观察到左心室（LV）舒张功能障碍。在老年受试者中也经常见到主动脉间隔角度（ASA）的减小（由于主动脉伸长引起的LV形状改变）。这项研究的目的是评估它是否可以促进健康受试者的LV舒张功能障碍。方法：对77名健康受试者（42名男性，平均年龄43.2±13.8岁）进行超声心动图检查，以测量ASA，舒张早期穿刺血流速度（E），等容舒张时间（IRT）和舒张早期二尖瓣环速度（e'）。 ）。 LV峰值舒张早期纵向应变率（GSRE）使用二维斑点跟踪成像技术进行了测量。结果：ASA与E（r = 0.54，p <0.001），IRT（r = -0.41，p <0.001），e'（r = 0.57，p <0.001）和GSRE（r = 0.63，p）显着相关<0.001），并通过逐步多变量分析显示，它是E，IRT和GSRE的最强独立决定因素，也是e'的独立决定因素之一。结论：ASA降低所致的LV形状改变可能是健康受试者中LV舒张功能障碍的原因之一，与年龄无关。

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