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首页> 外文期刊>Journal of Clinical Ultrasound: JCU >BI-RADS category 3 nonpalpable breast masses on sonography: Long-term results of a prospective cohort study
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BI-RADS category 3 nonpalpable breast masses on sonography: Long-term results of a prospective cohort study

机译：超声检查中BI-RADS第3类不可触及的乳腺肿块：一项前瞻性队列研究的长期结果

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Purpose: To determine the frequency of BI-RADS category 3 nonpalpable masses detected using only sonography (US) and the malignancy rate among these lesions. Second, to validate a proposed short-term follow-up regimen based on long-term observational results. Methods: This prospective cohort study was conducted between September 2003 and April 2010. We conducted a 2-year short-term follow-up protocol composed of five US examinations at 3-month intervals for the first 6 months, and at 6-month intervals for the next 18 months, followed with age-appropriate screenings. Biopsy was recommended for the masses increasing in size and with changing imaging features. Results: The frequency of category 3 nonpalpable masses detected only on US in 11,373 consecutive women was 5.3%. Of 562 lesions found in 451 women, 394 (70.1%) remained stable during the short-term and subsequent follow-up. Seventy-four (13.1%) masses showed interval regression and 79 (14.0%) showed interval progression. The malignancy rate was 0.3% (2 of 562), with about 85% of interval changes occurring within the first 2 years. The negative predictive value of US in the detection of cancer was 99.6% (95% CI, 98.7-99.9). The mean follow-up time was 65.5 ± 8.7 months. Conclusions:: The frequency of BI-RADS 3 nonpalpable masses detected using sonography alone was 5.3%. During follow-up, the majority of interval changes occurred within the first 2 years. Because these masses have a very low malignancy rate, a 2-year follow-up instead of immediate biopsy is an appropriate option.
机译：目的：确定仅使用超声（US）检查发现的BI-RADS 3类不可触及肿块的频率以及这些病变中的恶性率。第二，根据长期观察结果验证拟议的短期随访方案。方法：这项前瞻性队列研究在2003年9月至2010年4月之间进行。我们进行了为期2年的短期随访方案，该方案由前6个月和6个月的间隔为5个月的美国检查组成。接下来的18个月，然后进行适合年龄的筛查。建议对体积增大且影像学特征改变的肿块进行活检。结果：仅在美国连续11373名女性中检测到的3类不可触及肿块的发生率为5.3％。在451名妇女中发现的562个病变中，有394个（70.1％）在短期和随后的随访中保持稳定。七十四（13.1％）个肿块显示出间隔消退，而79个肿块（14.0％）显示出间隔进展。恶性肿瘤的发生率为0.3％（562例中的2例），间隔的大约85％发生在头2年内。 US在检测癌症中的阴性预测值为99.6％（95％CI，98.7-99.9）。平均随访时间为65.5±8.7个月。结论：仅通过超声检查发现的BI-RADS 3不可触及肿块的发生率为5.3％。在随访期间，大多数间隔变化发生在头2年内。由于这些肿块的恶性率非常低，因此两年随访而不是立即进行活检是一种合适的选择。

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