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首页> 外文期刊>Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology >Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia.
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Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia.

机译：在社区获得性肺炎患儿中，人类鼻病毒C感染与人类鼻病毒A相似。

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BACKGROUND: Human rhinoviruses (HRVs) are among the most common causes of community-acquired pneumonia (CAP) in children. However, the differential roles of the three HRV species HRV-A, HRV-B, and HRV-C in pediatric CAP are not fully understood. OBJECTIVE: To determine the distribution of HRV species and their roles in children hospitalized with CAP in Beijing, China. STUDY DESIGN: Nasopharyngeal aspirates were collected between April 2007 and March 2008 from 554 children with a primary diagnosis of CAP. HRVs in the clinical samples were detected by RT-PCR and by sequencing. Infections with other respiratory viruses were identified by PCR. RESULTS: HRVs were detected in 99 patients (17.87%). Among these patients, 51.52% tested positive for HRV-A, 38.38% for HRV-C, and 10.10% for HRV-B. HRVs were detected throughout the study period. The monthly distribution of HRV infections varied with HRV species. Median age, gender, symptoms, severity, and duration of hospitalization for single HRV-C infections were similar to those observed for single HRV-A infections. Co-infections with other respiratory viruses were detected in 57.58% of the HRV-positive children. HRV/RSV dual infections were correlated with a higher frequency of shortness of breath (HRV-A group, P(2 tail)= 0.01; HRV-C group, P(2 tail) = 0.015) and lower median ages (HRV-A group, P(2 tail) = 0.049; HRV-C group, P(2 tail) = 0.009). CONCLUSION: Our study shows that HRV-C strains circulate at a prevalence intermediate between HRV-A and HRV-B. The severity of clinical manifestations for HRV-C is comparable to that for HRV-A in children with CAP. These findings point to an important role of both HRV-A and HRV-C in pediatric CAP.
机译：背景：人类鼻病毒（HRV）是儿童社区获得性肺炎（CAP）的最常见原因。但是，尚未完全了解三种HRV种类HRV-A，HRV-B和HRV-C在儿科CAP中的不同作用。目的：确定中国北京地区CAP住院儿童的HRV种类分布及其作用。研究设计：自2007年4月至2008年3月，从554名主要诊断为CAP的儿童中收集了鼻咽抽吸物。通过RT-PCR和测序检测临床样品中的HRV。通过PCR鉴定了其他呼吸道病毒的感染。结果：99例患者中检出了HRVs（17.87％）。在这些患者中，有51.52％的HRV-A检测阳性，HRV-C的检测率为38.38％，HRV-B的检测为10.10％。在整个研究期间均检测到HRV。 HRV感染的每月分布因HRV种类而异。单个HRV-C感染的中位年龄，性别，症状，严重程度和住院时间与单个HRV-A感染的中位数相似。在57.58％的HRV阳性儿童中发现了与其他呼吸道病毒的合并感染。 HRV / RSV双重感染与呼吸急促发生的频率较高相关（HRV-A组，P（2尾巴）= 0.01; HRV-C组，P（2尾巴）= 0.015）和较低的中位年龄（HRV-A组，P（2尾）= 0.049; HRV-C组，P（2尾）= 0.009）。结论：我们的研究表明，HRV-C株在HRV-A和HRV-B之间的流行中间传播。 CAP患儿HRV-C的临床表现严重程度与HRV-A相当。这些发现表明HRV-A和HRV-C在小儿CAP中均具有重要作用。

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