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首页> 外文期刊>Journal of Comparative Pathology >Salivary Gland Epithelial-Myoepithelial Carcinoma with High-Grade Transformation in a Dog
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Salivary Gland Epithelial-Myoepithelial Carcinoma with High-Grade Transformation in a Dog

机译：唾液腺上皮-肌上皮癌与狗的高度转化

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An 8-year-old male neutered standard dachshund was presented with a slowly growing mass in the left submandibular salivary gland. Histopathological examination revealed a tumour that was composed of bilayered duct-like structures with an inner layer of ductal cells and an outer layer of clear cells. Both inner and outer cells in the greater part of the tumour exhibited low to moderate atypia and low mitotic activity. However, a focal area towards the periphery showed enhanced cellular atypia and mitotic activity in tumour cells. Immunohistochemically, the outer layer of clear cells expressed myoepithelial markers, while the inner layer cells were positive for a luminal epithelial marker. No local recurrence or lymph node or distant metastasis was observed 18 months following surgery. Based on the morphology and immunohistochemical findings, a final diagnosis of epithelial-myoepithelial carcinoma with high-grade transformation was made. (C) 2015 Elsevier Ltd. All rights reserved.
机译：出现了一个8岁的男性绝育标准腊肠犬，其左颌下唾液腺中的肿块缓慢增长。组织病理学检查显示肿瘤是由双层导管样结构组成，具有导管细胞的内层和透明细胞的外层。肿瘤大部分中的内部和外部细胞均表现出低至中度的异型性和低有丝分裂活性。然而，朝向外周的聚焦区域显示出肿瘤细胞中细胞的非典型性和有丝分裂活性增强。在免疫组织化学上，透明细胞的外层表达肌上皮标记，而内层细胞对腔上皮标记呈阳性。术后18个月未观察到局部复发或淋巴结转移或远处转移。基于形态学和免疫组织化学结果，对上皮-肌上皮癌进行高级别转化进行最终诊断。 （C）2015 Elsevier Ltd.保留所有权利。

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