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首页> 外文期刊>Journal of Comparative Pathology >Comparison of Experimental Infection with Northern and Southern Vietnamese Strains of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
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Comparison of Experimental Infection with Northern and Southern Vietnamese Strains of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

机译：越南北部和南部菌株高致病性猪繁殖与呼吸综合征病毒实验感染的比较

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The aim of this study was to compare the virulence of northern and southern Vietnamese strains of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) as assessed by the level of viral replication, gross and microscopical lung lesions and virus distribution in experimentally infected pigs. The northern and southern Vietnamese HP-PRRSV strains share 96.7% (non-structural protein 2) and 99.3% (open reading frame 5) nucleotide identity. On experimental challenge, approximately 50% of pigs infected with northern Vietnamese HP-PRRSV died, while death was not observed in any pigs infected with southern Vietnamese HP-PRRSV. Mean viral titres (expressed as log(10)TCID(50)/ml) were significantly (P0.05) higher in sera and lungs from pigs infected with the northern Vietnamese HP-PRRSV than from those infected with the southern Vietnamese strain at multiple time points. Lung lesion scores and PRRSV antigen within pulmonary and lymphoid lesions were significantly (P0.05) higher in pigs infected with northern Vietnamese HP-PRRSV than in those receiving southern Vietnamese HP-PRRSV at multiple time points. PRRSV antigens were observed in cardiac myocytes, gastric and renal tubular epithelial cells and astrocytes and microglia of white matter in the brain from pigs infected with the northern Vietnamese HP-PRRSV strain only. Thus, genetic similarity did not predict the degree of virulence of these strains. Northern Vietnamese HP-PRRSV was more virulent and had extended tissue tropism when compared with southern Vietnamese HP-PRRSV. (C) 2014 Elsevier Ltd. All rights reserved.
机译：这项研究的目的是比较越南北部和南部越南高致病性猪繁殖与呼吸综合征病毒（HP-PRRSV）毒株的毒力，方法是通过病毒复制水平，肉眼和肺部微观病变以及实验感染的病毒分布来评估猪。越南北部和南部的HP-PRRSV菌株共有96.7％（非结构蛋白2）和99.3％（开放阅读框5）核苷酸同一性。在实验性挑战中，感染越南北部HP-PRRSV的猪中约有50％死亡，而感染越南南部HP-PRRSV的任何猪均未观察到死亡。在越南北部HP-PRRSV感染的猪中，血清和肺中的平均病毒滴度（表示为log（10）TCID（50）/ ml）显着（P <0.05）比在越南越南HP-PRRSV感染的猪的血清和肺中多时间点。在多个时间点，感染越南北部HP-PRRSV的猪的肺部病变评分和肺和淋巴样病变内的PRRSV抗原均显着高于（P <0.05）。仅感染了越南北部HP-PRRSV株的猪的心肌细胞，胃和肾小管上皮细胞，星形胶质细胞和脑中的白质小胶质细胞中观察到PRRSV抗原。因此，遗传相似性不能预测这些菌株的毒力程度。与越南南部HP-PRRSV相比，越南北部HP-PRRSV更具毒性，并且组织嗜性更广。 （C）2014 Elsevier Ltd.保留所有权利。

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