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首页> 外文期刊>Clinical Biochemistry >Association of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy.
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Association of methylenetetrahydrofolate reductase T677 allele with early development of chronic allograft nephropathy.

机译：亚甲基四氢叶酸还原酶T677等位基因与慢性同种异体肾病的早期发展相关。

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Objectives: The aim of this study was to evaluate the role of genetic polymorphisms on the development of chronic allograft nephropathy (CAN). Design and methods: Using the polymerase chain reaction (PCR), polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T), interleukin-6 (IL-6 G-174C) and CD14 (C-260T) were evaluated in 92 kidney transplant recipients with stable renal graft function and no signs of acute rejection in a protocol that included graft biopsy at 12 months after kidney transplantation. A normal population sample (n = 365) was also included. Multivariate analysis was used to evaluate the effect of different variables on the CAN appearance. Results: There were no differences in alleles and genotypes distribution between transplant group and normal population sample. The CAN+ group (n = 69) significantly differed from CAN- (n = 23) in both MTHFR (P < 0.05) and IL-6 (P < 0.01) genotype distribution. Using logistic regression multivariate analysis, MTHFR T677 allele (OR: 3.91, CI: 1.11-13.8; P < 0.05), patient age (OR: 0.94, CI: 0.88-0.98; P < 0.01) and proteinuria (OR: 3.63, CI: 1.25-10.6; P < 0.05) were associated with CAN. Although the IL-6 G-174 allele was shown to be associated with CAN development in univariate analysis (P < 0.01), the multivariate analysis did not show an association. There was no relation between CD14 gene polymorphism and CAN. Conclusion: The MTHFR T677 allele is associated with the presence of CAN in kidney graft biopsies 12 months after transplantation.
机译：目的：本研究的目的是评估遗传多态性在慢性同种异体肾病（CAN）发展中的作用。设计与方法：使用聚合酶链反应（PCR），对92例肾功能稳定的肾脏移植受者评估了亚甲基四氢叶酸还原酶（MTHFR C677T），白介素6（IL-6 G-174C）和CD14（C-260T）的多态性。包括肾移植后12个月的活检的方案中没有移植物的功能，也没有急性排斥反应的迹象。还包括正常人群样本（n = 365）。多变量分析用于评估不同变量对CAN外观的影响。结果：移植组与正常人群之间的等位基因和基因型分布无差异。 CAN +组（n = 69）在MTHFR（P <0.05）和IL-6（P <0.01）基因型分布上与CAN-（n = 23）有显着差异。使用logistic回归多元分析，MTHFR T677等位基因（OR：3.91，CI：1.11-13.8; P <0.05），患者年龄（OR：0.94，CI：0.88-0.98; P <0.01）和蛋白尿（OR：3.63，CI ：1.25-10.6; P <0.05）与CAN相关。尽管在单变量分析中显示IL-6 G-174等位基因与CAN发育相关（P <0.01），但多变量分析未显示相关性。 CD14基因多态性与CAN之间没有关系。结论：MTHFR T677等位基因与移植后12个月的肾移植活检中CAN的存在有关。

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