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首页> 外文期刊>Journal of Colloid and Interface Science >Effects of gamma radiation on phase behaviour and critical micelle concentration of Triton X-100 aqueous solutions
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Effects of gamma radiation on phase behaviour and critical micelle concentration of Triton X-100 aqueous solutions

机译：γ射线对Triton X-100水溶液的相行为和临界胶束浓度的影响

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摘要

Ionising radiation used for sterilization can have an effect on the physicochemical properties of pharmaceutically relevant excipient systems, affecting therefore the stability of the formulation. The effect of gamma irradiation on the phase behaviour (cloud point-CP) and critical micelle concentration (CMC) of aqueous solutions of Triton X-100, used as a model nonionic surfactant, is investigated in this paper. Micellar solutions were it-radiated with gamma-rays in a dose range between 0 and 70 kGy, including the sterilization range of pharmaceutical preparations. The decreased observed in CP and CMC values of micellar solutions at all absorbed doses was explained in terms of changes in molecular mass distribution of ethoxylated surfactant and the formation of cross-linked species. These results were complemented by mass spectrometry, UV-vis and NMR spectroscopy. Although the findings indicate degradation of polyethoxylated chains by water radical attacks, there was no spectroscopic evidence of radiation damage to aromatic ring or hydrocarbon tail of surfactant. Models based on Flory-Huggins theory were employed to estimate CP from changes in mass distribution and to obtain cross-linking fractions. Surface tension measurements of non-irradiated and irradiated solutions were used for estimating the effectiveness and efficiency of surfactant in the formulation. (C) 2007 Elsevier Inc. All rights reserved.
机译：用于灭菌的电离辐射可对药学上相关的赋形剂系统的物理化学性质产生影响，因此影响制剂的稳定性。本文研究了γ辐照对Triton X-100（用作模型非离子表面活性剂）水溶液的相行为（浊点-CP）和临界胶束浓度（CMC）的影响。用0至70 kGy的剂量范围（包括药物制剂的灭菌范围）的伽马射线辐射胶束溶液。在所有吸收剂量下，胶束溶液的CP和CMC值均下降，这是根据乙氧基化表面活性剂的分子量分布变化和交联物种的形成来解释的。质谱，紫外可见和NMR光谱对这些结果进行了补充。尽管这些发现表明聚乙氧基化链因水基自由基的攻击而降解，但没有光谱学证据表明辐射破坏了表面活性剂的芳环或烃尾。使用基于Flory-Huggins理论的模型从质量分布的变化估计CP，并获得交联分数。使用未辐照溶液和辐照溶液的表面张力测量值来评估配方中表面活性剂的有效性和效率。 （C）2007 Elsevier Inc.保留所有权利。

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