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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Survival of glioblastoma patients related to presenting symptoms, brain site and treatment variables.
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Survival of glioblastoma patients related to presenting symptoms, brain site and treatment variables.

机译：胶质母细胞瘤患者的生存与症状，大脑部位和治疗变量有关。

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This retrospective study of 133 patients with glioblastoma multiforme evaluates survival times post-radiation in patients stratified in respect to age, presenting symptoms, tumour location, extent of surgery, and radiation dose delivered. Presenting features were coded as seizure, loss of consciousness, headache, speech or visual disturbance, weakness and confusion, as were tumour sites within the brain. Other parameters assessed included side of brain, age, extent of surgery and radiation dose. Statistical evaluation was undertaken by univariate and multivariate analyses to identify factors leading to enhanced survival. The median survival post-radiation was 10 months. A trend to improved early survival was demonstrated in patients presenting with acute and debilitating symptoms. The data presented reveals improved outcomes for patients younger than 60 years, particularly if radical surgery is undertaken with higher dose radiation. It is postulated that patients presenting with acute signs and symptoms are investigated earlier and are referred more promptly for treatment.
机译：这项对133例多形性胶质母细胞瘤患者的回顾性研究评估了按年龄，症状，肿瘤位置，手术范围和放射剂量分层的分层患者的放射后生存时间。表现特征被编码为癫痫发作，意识丧失，头痛，语言或视觉障碍，虚弱和精神错乱，大脑中的肿瘤部位也被编码。评估的其他参数包括脑侧，年龄，手术范围和放射剂量。通过单因素和多因素分析进行​​统计评估，以确定导致生存率提高的因素。放射后中位生存期为10个月。表现出急性和虚弱症状的患者表现出改善早期生存的趋势。所提供的数据表明，对于60岁以下的患者，其转归有所改善，特别是如果采用更高剂量的放射线进行根治性手术时。假设对表现出急性体征和症状的患者进行了更早的调查，并可以更迅速地转诊接受治疗。

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