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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.
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Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury.

机译：比较奥曲肽和褪黑激素预防实验性脊髓损伤大鼠神经损伤的作用。

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In this study, we aimed to investigate the biochemical and histopathological protective effects of octreotide and melatonin in an experimental model of spinal cord injury. Fifty- six male albino Wistar rats were divided into four groups. Rats in the G1 group (n=7; control group) did not undergo any treatment except for anesthesia prior to being killed. Rats in the G2 group (n=7) underwent laminectomy and aneurysmal clip application at the T4-5 level. G3 group rats (n=14) were either treated with a 7.5 mg/kg intraperitoneal dose of melatonin (Sigma, St. Louis, MO, USA) immediately after laminectomy, then the same dose again on the day following injury (G3a), or given three equal doses over 10 days to achieve a total dose of 7.5 mg/kg/day (G3b). G4 group rats (n=14) were either treated with a 30mug/kg intraperitoneal dose of octreotide (Sandostatin; Novartis, Istanbul, Turkey) immediately after laminectomy, then the same dose again on the day following injury (G4a), or given three equal doses over 10 days to achieve a total dose of 30mug/kg/day (G4b). Rats in the G3 and G4 groups were sacrificed on days 1 and 10 after spinal cord injury (n=7 at each time point) and spinal cord samples were obtained. Tissue malonyldialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels were assayed. G3a, G3b and G4b had significantly lower levels of MDA than G2 (p<0.01). G3b had significantly higher SOD and GSH-Px levels than G2 (p<0.01). Histopathologically, melatonin significantly reduced necrosis and degeneration in both the initial and late stages (p<0.01). Octreotide had significant effects on necrosis and degeneration during the late stages, and on edema and congestion in both the initial and the late stages of injury (p<0.01). Melatonin was found to be superior to octreotide with respect to the prevention of congestion, edema, axonal degeneration and necrosis.
机译：在这项研究中，我们旨在研究奥曲肽和褪黑激素在脊髓损伤实验模型中的生化和组织病理学保护作用。将56只雄性白化病Wistar大鼠分为四组。 G1组（n = 7;对照组）除处死前麻醉外未进行任何治疗。 G2组（n = 7）的大鼠在T4-5水平进行了椎板切除术和动脉瘤夹应用。 G3组大鼠（n = 14）或在椎板切除术后立即用7.5 mg / kg腹膜内剂量的褪黑激素（Sigma，圣路易斯，密苏里州，美国）治疗，然后在受伤后第二天再次给予相同剂量的G3a，或在10天内给予三等分剂量，以达到7.5 mg / kg /天的总剂量（G3b）。 G4组大鼠（n = 14）或者在椎板切除术后立即用30mug / kg的腹膜内剂量的奥曲肽（Sandostatin; Novartis，伊斯坦布尔，土耳其）治疗，然后在受伤的第二天再次给予相同剂量的剂量（G4a），或给予三只在10天内平均剂量，以达到30 ug / kg /天的总剂量（G4b）。 G3和G4组的大鼠在脊髓损伤后第1天和第10天处死（每个时间点n = 7）并获得脊髓样品。分析了组织丙二醛（MDA），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的水平。 G3a，G3b和G4b的MDA水平明显低于G2（p <0.01）。 G3b的SOD和GSH-Px水平明显高于G2（p <0.01）。在组织病理学上，褪黑激素在初期和晚期均显着减少了坏死和变性（p <0.01）。奥曲肽对晚期坏死和变性以及损伤初期和晚期的水肿和充血有显着影响（p <0.01）。在预防充血，水肿，轴突变性和坏死方面，发现褪黑激素优于奥曲肽。

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