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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Outcomes and patterns of care in adult skull base chondrosarcomas from the SEER database
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Outcomes and patterns of care in adult skull base chondrosarcomas from the SEER database

机译：SEER数据库中成人颅底软骨肉瘤的治疗结果和模式

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This study aims to demonstrate survival rates and treatment patterns among patients with chondrosarcomas of the skull base using a large population database. Patients with skull base chondrosarcomas between 1973 and 2009 were identified from the USA Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier survival analysis was used to examine the effect of surgery and radiation on overall survival. We identified 226 patients with skull base chondrosarcomas. Median follow-up was 5.4 years. Median overall survival was 22 years, and 10 year survival was 68.2%. Most patients underwent surgery (92.5%). Few received radiation after diagnosis (38.1%). Ten year survival for all patients treated with surgery was significantly increased compared to those without surgery (69.3% versus 53.9%, p = 0.02). There was a significant difference in survival amongst treatment groups (p = 0.02), with median overall survival not yet reached for patients who received surgery and radiation (median follow-up 5.3 years), compared to 22 years for non-irradiated surgical patients. Surgery predicted better overall survival by univariate analysis (hazard ratio [HR] 0.420, p = 0.03). Female sex (HR 0.470, p = 0.011), younger age at diagnosis (HR 1.046, p < 0.0001), and later year of diagnosis (HR 0.949, p = 0.0006) were prognostic of improved survival in a multivariate model. In subgroup analysis of patients with documented tumor size, smaller tumor size (HR 1.054, p = 0.0003) and younger age (HR 1.021, p = 0.0067) predicted improved survival. This population based study further reaffirms the role of surgery as an effective treatment for skull base chondrosarcoma as previously reported in small case series. Adjuvant radiation may also confer survival benefit. Optimal treatment strategy has yet to be defined in the literature.
机译：这项研究的目的是使用大量的数据库来证明颅底软骨肉瘤患者的生存率和治疗方式。从美国监测，流行病学和最终结果（SEER）数据库中识别出1973年至2009年之间患有颅底软骨肉瘤的患者。 Kaplan-Meier生存分析用于检查手术和放疗对总体生存的影响。我们确定了226例颅底软骨肉瘤患者。中位随访时间为5。4年。中位总生存期为22年，而10年生存率为68.2％。大多数患者接受了手术（92.5％）。诊断后很少接受放射治疗（38.1％）。与未进行手术的患者相比，所有接受手术治疗的患者的十年生存率均显着提高（69.3％对53.9％，p = 0.02）。各治疗组之间的生存率存在显着差异（p = 0.02），接受手术和放射治疗的患者（中位随访时间为5.3年）尚未达到中位总体生存，而未接受辐照的手术患者为22年。手术通过单因素分析预测总体生存率更高（危险比[HR] 0.420，p = 0.03）。在多变量模型中，女性（HR 0.470，p = 0.011），诊断时较年轻（HR 1.046，p <0.0001）和诊断年晚（HR 0.949，p = 0.0006）预后良好。在已记录肿瘤大小的患者的亚组分析中，较小的肿瘤大小（HR 1.054，p = 0.0003）和较年轻的年龄（HR 1.021，p = 0.0067）可预测存活率的提高。这项基于人群的研究进一步证实了手术作为颅底软骨肉瘤的有效治疗方法的作用，如先前在小病例系列中报道的那样。辅助放射也可能带来生存益处。最佳治疗策略尚未在文献中定义。

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