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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >Central nervous system involvement in hepatocellular carcinoma: clinical characteristics and comparison of intracranial and spinal metastatic groups.
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Central nervous system involvement in hepatocellular carcinoma: clinical characteristics and comparison of intracranial and spinal metastatic groups.

机译：中枢神经系统参与肝细胞癌的临床特征以及颅内和脊柱转移组的比较。

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摘要

From January 1993 to December 2006 we analyzed the clinical characteristics of patients with hepatocellular carcinoma (HCC) with central nervous system (CNS) metastasis at the Kaohsiung Chang Gung Memorial Hospital, Taiwan. Forty-six patients with HCC and CNS metastasis were identified, of whom 36 had intracranial metastasis and 10 had spinal metastasis. The clinical presentations, laboratory data and imaging studies were collected and analyzed. The age at the time of HCC diagnosis ranged from 34 to 78 years; CNS metastasis occurred between 0 and 85 months after diagnosis and death followed between 0 and 93 months later. The Glasgow Coma Scale (GCS) score at the time of CNS metastasis ranged from 7 to 15 and the Child-Pugh score at diagnosis of HCC ranged from 5 to 15. Patients with spinal metastasis had a higher GCS score and lower Child-Pugh score at diagnosis. None of the serum biochemical studies showed unique abnormalities. From the data currently available, intracranial metastasis is the most common site of CNS metastasis of HCC. Advances in treating and diagnosing HCC have improved patient outcomes remarkably; however, CNS metastasis continues to have a grave prognosis. Without a specific biomarker for predicting CNS involvement in HCC, a high index of suspicion for the diagnosis should be maintained, particularly in HCC hyperendemic areas such as Taiwan.
机译：从1993年1月至2006年12月，我们在台湾高雄长庚纪念医院分析了具有中枢神经系统（CNS）转移的肝细胞癌（HCC）患者的临床特征。确定了46例HCC和CNS转移患者，其中36例发生颅内转移，10例发生脊柱转移。收集并分析了临床表现，实验室数据和影像学研究。诊断HCC时的年龄为34至78岁;中枢神经系统转移发生在诊断后0至85个月之间，死亡发生在0至93个月后。中枢神经系统转移时的格拉斯哥昏迷量表（GCS）评分为7至15，诊断HCC时的Child-Pugh评分为5至15。脊柱转移的患者GCS评分较高，Child-Pugh评分较低诊断时。血清生化研究均未显示出异常。从目前可获得的数据来看，颅内转移是肝癌中枢神经转移最常见的部位。 HCC的治疗和诊断方面的进展显着改善了患者的预后。然而，中枢神经系统转移仍然具有严重的预后。如果没有用于预测中枢神经系统参与肝癌的特异性生物标志物，则应保持较高的诊断怀疑指数，尤其是在台湾等肝癌高流行地区。

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