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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population.
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A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population.

机译：一种临床记忆电池，用于筛查中国老年人群的轻度认知障碍。

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摘要

Amnestic mild cognitive impairment (MCI) might be more likely to progress to Alzheimer's disease than single non-memory MCI and multiple domain MCI. After excluding those who did not conform to the inclusion criteria of amnestic MCI or healthy controls, a neuropsychologic battery that included the Mini-Mental State Examination, Clinical Dementia Rating, Chinese version of the Montreal Cognitive Assessment, Instrumental Activities of Daily Living scale and Auditory Verbal Learning Test was performed on 150 amnestic MCI and 150 normal control patients. The Chinese version of the Montreal Cognitive Assessment was measured for its test-retest reliability, sensitivity and specificity. Blood was collected for apolipoprotein E (APOE) genotyping. Compared with the control group, the amnestic MCI group performed significantly worse on all neuropsychological tests, and non-APOE-epsilon4 carriers in the amnestic MCI group performed better than APOE-epsilon4 carriers in the amnestic MCI group. The set of neuropsychological tests in our study could distinguish amnestic MCI participants from normal elderly participants accurately. APOE did have a role in amnestic MCI patients, but the magnitude and mechanism of its influence are not fully understood.
机译：轻度轻度认知障碍（MCI）可能比单一的非记忆MCI和多领域MCI更容易发展为阿尔茨海默氏病。在排除那些不符合记忆删除MCI或健康对照的入选标准的人之后，神经心理电池包括了迷你精神状态检查，临床痴呆等级，中文版的蒙特利尔认知评估，日常工具活动量表和听觉对150名记忆删除的MCI和150名正常对照患者进行了口语学习测试。测量了蒙特利尔认知评估中文版的重测信度，敏感性和特异性。收集血液用于载脂蛋白E（APOE）基因分型。与对照组相比，记忆删除MCI组在所有神经心理学测试中的表现均明显较差，记忆删除MCI组中非APOE-ε4携带者的表现优于记忆删除MCI组中的APOE-ε4携带者。在我们的研究中，一组神经心理学测试可以准确地区分失忆MCI参与者与正常老年人。 APOE在MCI记忆删除患者中确实发挥了作用，但其影响的程度和机制尚不完全清楚。

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