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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >The effects of valproic acid and levetiracetam on chicken embryos.
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The effects of valproic acid and levetiracetam on chicken embryos.

机译：丙戊酸和左乙拉西坦对鸡胚的影响。

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For patients with epilepsy, anti-epileptic medication is generally the first line of treatment, but treating pregnant women with epilepsy can be a challenge. Standard anti-epileptic medications have caused developmental abnormalities, so much effort has been put into developing antiepileptic medications with minimal teratogenic effects. In this experimental study, the new-generation anti-epileptic medication levetiracetam and the standard anti-epileptic medication valproic acid were compared in terms of teratogenicity by studying embryonic development in 360 fertile White-Leghorn chicken eggs (conception day 0). We found that levetiracetam may cause severe developmental abnormalities, and is likely not safe for use in pregnant women. As expected, valproic acid caused more frequent developmental abnormalities than levetiracetam, and the risk increased still further when both drugs were administered in combination. Levetiracetam should be used cautiously in pregnant women with epilepsy.
机译：对于癫痫患者，抗癫痫药通常是治疗的第一线，但是治疗癫痫孕妇可能是一个挑战。标准的抗癫痫药已引起发育异常，因此已投入大量精力开发具有最小致畸作用的抗癫痫药。在这项实验研究中，通过研究360个可育的白来格霍恩鸡卵的胚胎发育，比较了新一代抗癫痫药物左乙拉西坦和标准抗癫痫药物丙戊酸的致畸性（受孕第0天）。我们发现左乙拉西坦可能会导致严重的发育异常，并且可能不适用于孕妇。正如预期的那样，丙戊酸比左乙拉西坦引起更频繁的发育异常，并且两种药物合用时，风险进一步增加。癫痫孕妇应谨慎使用左乙拉西坦。

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