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首页> 外文期刊>Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia >The acute effects of levetiracetam on nocturnal sleep and daytime sleepiness in patients with partial epilepsy
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The acute effects of levetiracetam on nocturnal sleep and daytime sleepiness in patients with partial epilepsy

机译：左乙拉西坦对部分癫痫患者的夜间睡眠和白天嗜睡的急性影响

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摘要

This study investigated the effect of the novel antiepileptic drug levetiracetam (LEV) on sleep in eleven patients with partial epilepsy. At baseline and one week after therapy with LEV (1000 mg/day), patients underwent polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT). Patients also rated their own degree of sleep disturbance and daytime sleepiness with the Athens Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS). A group of 10 age- and gender-matched control participants were also included in the study. Patients had decreased total sleep time and increased daytime sleepiness compared to baseline, as evaluated by AIS subscales. Furthermore, LEV therapy significantly decreased the rapid eye movement sleep time and percentage as measured by PSG. Patients reported a significant increase in ESS score but did not exhibit changes in MSLT performance after LEV treatment. The study demonstrated that short-course LEV treatment can affect subjective sleep time and objective sleep architecture. Furthermore, LEV treatment affected subjective daytime sleepiness but did not influence objective mean daytime sleep latencies in patients with partial epilepsy.
机译：这项研究调查了新型抗癫痫药左乙拉西坦（LEV）对11例部分性癫痫患者睡眠的影响。在基线水平和LEV（1000 mg /天）治疗后的一周，患者接受了多导睡眠图（PSG）和多睡眠潜伏期测试（MSLT）。患者还用雅典失眠量表（AIS）和爱泼华嗜睡量表（ESS）对自己的睡眠障碍和白天嗜睡程度进行了评估。这项研究还包括一组10位年龄和性别匹配的对照参与者。通过AIS量表评估，与基线相比，患者的总睡眠时间减少，白天嗜睡程度增加。此外，通过PSG测量，LEV治疗显着减少了快速眼动睡眠时间和百分比。患者报告ESS评分显着增加，但LEV治疗后MSLT表现未见变化。该研究表明，短程LEV治疗可影响主观睡眠时间和客观睡眠结构。此外，LEV治疗影响部分癫痫患者的主观白天睡眠，但不影响客观平均白天睡眠潜伏期。

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