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首页> 外文期刊>Journal of Clinical Oncology >Health-related quality of life results in pathologic stage C prostate cancer from a Southwest Oncology Group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy.
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Health-related quality of life results in pathologic stage C prostate cancer from a Southwest Oncology Group trial comparing radical prostatectomy alone with radical prostatectomy plus radiation therapy.

机译：与健康相关的生活质量导致一项西南肿瘤小组的临床C阶段病理性前列腺癌的比较，该试验比较了单纯根治性前列腺切除术与根治性前列腺切除术加放射疗法的比较。

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PURPOSE: To compare short- and long-term effects of adjuvant treatment versus observation after surgery on health-related quality of life (HRQL) of prostate cancer patients. PATIENTS AND METHODS: The Southwest Oncology Group (SWOG) intergroup trial compared radical prostatectomy (RP) plus observation versus RP plus adjuvant radiation therapy (RT). Two-hundred seventeen of 425 therapeutic trial patients were eligible and registered to the HRQL study. Patients completed the SWOG Quality of Life Questionnaire (emotional, physical, social, and role function; general symptom status; treatment/disease-specific symptoms; and global HRQL [GHRQL]) at baseline, 6 weeks, 6 months, and annually for 5 years. Prespecified outcomes were three genitourinary symptoms (bowel function tenderness, frequent urination, and erectile dysfunction [ED]) and measures of physical and emotional function. Adjustments were made for the baseline score. RESULTS: Patients receiving adjuvant RT reported worse bowel function (through approximately 2 years) and worse urinary function. There were no statistically significant differences for ED. GHRQL was initially worse for the RP+RT arm but improved over time and was better at the end of the period than the GHRQL reported for RP alone (treatment arm x time interaction, P = .0004). Symptom distress was significantly worse for the RP+RT arm compared with the RP alone arm, but the treatment arms did not differ with respect to other general measures of HRQL. CONCLUSION: The addition of RT to surgery resulted in more frequent urination, as well as early report of more bowel dysfunction, although bowel function differences disappeared over the 5-year period. The addition of RT did not negatively impact ED.
机译：目的：比较辅助治疗和术后观察对前列腺癌患者健康相关生活质量（HRQL）的短期和长期影响。患者和方法：西南肿瘤小组（SWOG）的小组间试验比较了根治性前列腺切除术（RP）加观察与RP加辅助放射疗法（RT）的比较。 425名治疗试验患者中有217名符合条件并注册了HRQL研究。患者在基线，6周，6个月和每年5次的时间内完成SWOG生活质量问卷（情绪，身体，社会和角色功能;一般症状状态;治疗/疾病特异性症状;总体HRQL [GHRQL]）年份。预先确定的结局是三种泌尿生殖系统症状（大肠功能压痛，尿频和勃起功能障碍[ED]）以及身体和情绪功能的指标。对基线得分进行了调整。结果：接受辅助放疗的患者报告肠功能较差（大约2年）和尿功能较差。 ED没有统计学上的显着差异。最初，RP + RT组的GHRQL较差，但随着时间的推移有所改善，并且期末比单独报告RP的GHRQL更好（治疗组x时间相互作用，P = .0004）。与单独使用RP的手臂相比，使用RP + RT的手臂的症状困扰明显更糟，但是就HRQL的其他一般指标而言，治疗的手臂没有差异。结论：尽管在5年的时间里肠道功能差异消失了，但在外科手术中增加RT导致排尿更为频繁，并早期报道了更多的肠道功能障碍。添加RT不会对ED产生负面影响。

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