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首页> 外文期刊>Journal of Clinical Oncology >Quality of life of patients with endometrial cancer undergoing laparoscopic international federation of gynecology and obstetrics staging compared with laparotomy: a Gynecologic Oncology Group study.
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Quality of life of patients with endometrial cancer undergoing laparoscopic international federation of gynecology and obstetrics staging compared with laparotomy: a Gynecologic Oncology Group study.

机译：接受腹腔镜国际妇产科联合妇产科分期手术与开腹手术的子宫内膜癌患者的生活质量：妇科肿瘤小组的一项研究。

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PURPOSE: The study's objective was to compare the quality of life (QoL) of patients with endometrial cancer undergoing surgical staging via laparoscopy versus laparotomy. PATIENTS AND METHODS: The first 802 eligible patients (laparoscopy, n = 535; laparotomy, n = 267) participated in the QoL study in a Gynecologic Oncology Group (GOG) randomized trial of laparoscopy versus laparotomy (GOG 2222). Patients completed QoL assessments at baseline; at 1, 3, and 6 weeks; and at 6 months postsurgery. RESULTS: In an intent-to-treat analysis, laparoscopy patients reported significantly higher Functional Assessment of Cancer Therapy-General (FACT-G) scores (P = .001), better physical functioning (P = .006), better body image (BI; P < .001), less pain (P < .001) and its interference with QoL (P < .001), and an earlier resumption of normal activities (P = .003) and return to work (P = .04) over the 6-week postsurgery period, as compared with laparotomy patients. However, the differences in BI and return to work between groups were modest, and the adjusted FACT-G scores did not meet the minimally important difference (MID) between the two surgical arms over 6 weeks. By 6 months, except for better BI in laparoscopy patients (P < .001), the difference in QoL between the two surgical techniques was not statistically significant. CONCLUSION: Although the FACT-G did not show a MID between the two surgical groups, and only modest differences in return to work and BI were found between the two groups, statistically significantly better QoL across many parameters in the laparoscopy arm at 6 weeks provides modest support for the QoL advantage of using laparoscopy to stage patients with early endometrial cancer.
机译：目的：本研究的目的是比较接受腹腔镜手术与剖腹手术的子宫内膜癌患者进行手术分期的生活质量（QoL）。患者与方法：首批802例合格患者（腹腔镜检查，n = 535;剖腹手术，n = 267）参加了妇科肿瘤学组（GOG）腹腔镜检查与开腹手术（GOG 2222）随机试验的QoL研究。患者在基线时完成了QoL评估;在1、3和6周时;术后6个月。结果：在意向治疗分析中，腹腔镜检查患者报告的癌症治疗常规功能评估（FACT-G）得分显着更高（P = .001），身体功能更好（P = .006），身体形象更好（ BI; P <.001），疼痛减轻（P <.001）及其对QoL的干扰（P <.001），以及较早恢复正常活动（P = .003）和恢复工作（P = .04 ），相比于剖腹手术患者，术后6周的手术时间更长。但是，各组之间BI和恢复工作的差异不大，经过调整的FACT-G评分在6周内未达到两个手术臂之间的最小重要差异（MID）。到6个月时，除了腹腔镜检查患者的BI更好（P <.001），两种手术技术之间的QoL差异均无统计学意义。结论：尽管FACT-G在两个手术组之间未显示MID，并且在两个手术组之间仅发现适度的返工率和BI差异，但在6周时，腹腔镜检查组中许多参数的QoL在统计学上明显更好对使用腹腔镜对早期子宫内膜癌患者进行分期的QoL优势的支持有限。

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