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首页> 外文期刊>Journal of Clinical Oncology >Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center.
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Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center.

机译：与大型临床医学中心的乳腺癌临床试验参与和注册相关的因素。

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PURPOSE: The practice patterns of medical oncologists at a large National Cancer Institute Comprehensive Cancer Center in Detroit, MI were evaluated to better understand factors associated with accrual to breast cancer clinical trials. PATIENTS AND METHODS: From 1996 to 1997, physicians completed surveys on 319 of 344 newly evaluated female breast cancer patients. The 19-item survey included clinical data, whether patients were offered clinical trial (CT) participation and enrollment, and when applicable, reasons why they were not. Multivariate analyses using logistic regression were performed to evaluate predictors of an offer and enrollment. RESULTS: The patients were 57% white, 32% black, and 11% other/unknown race. One hundred six (33%) were offered participation and 36 (34%) were enrolled. In multivariate analysis, CTs were less likely offered to older women (mean age, 52 years for those offered v 57 years for those not offered; P =.0005) and black women (21% of blacks offered v 42% of whites; P =.0009). Women with stage 1 disease, poor performance status, and those who were previously diagnosed were also less likely to be offered trials. None of these factors were significant predictors of enrollment. Women were not offered trials because of ineligibility (57%), lack of available trials (41%), and noncompliance (2%). Reasons for failed enrollment included patient refusal (88%) and failed eligibility (12%). CONCLUSION: It is important for cooperative groups to design studies that will accommodate a broader spectrum of patients. Further work is needed to assess ways to improve communication about breast cancer CT participation to all eligible women.
机译：目的：评估了密歇根州底特律市大型国家癌症研究所综合癌症中心的医学肿瘤学家的执业模式，以更好地了解与乳腺癌临床试验的累积相关的因素。患者与方法：从1996年到1997年，医生完成了对344位新评估的女性乳腺癌患者中319位的调查。这项19项调查包括临床数据，是否为患者提供了临床试验（CT）参与和入组，以及在适用的情况下不提供患者的原因。使用逻辑回归进行多元分析，以评估报价和入学人数的预测指标。结果：患者为57％的白人，32％的黑人和11％的其他/未知种族。一百六个（33％）被邀请参加，并且36（34％）被录取了。在多变量分析中，CT不太可能提供给老年妇女（平均年龄，被提供者为52岁，未提供者为57岁; P = .0005）和黑人妇女（提供黑人的21％，提供白人的42％; P = .0009）。患有1期疾病，表现不佳的女性以及先前被诊断出的女性也不太可能接受试验。这些因素都不是招生的重要预测指标。由于不合格（57％），缺乏可用的试验（41％）和违规（2％）而未向妇女提供试验。入选失败的原因包括患者拒绝（88％）和入选失败（12％）。结论：对于合作小组来说，设计能够容纳更多患者的研究非常重要。需要做进一步的工作，以评估改善与所有合格女性进行乳腺癌CT参与交流的方法。

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