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首页> 外文期刊>Journal of computational and theoretical nanoscience >Uniquimer: Software of de novo DNA sequence generation for DNA self-assembly - An introduction and the related applications in DNA self-assembly
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Uniquimer: Software of de novo DNA sequence generation for DNA self-assembly - An introduction and the related applications in DNA self-assembly

机译：Uniquimer：用于DNA自组装的从头DNA序列生成软件-DNA自组装的简介及其相关应用

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摘要

We developed a computer-software, Uniquimer, with graphic interfaces for generating de novo DNA sequences of various DNA motifs for DNA nanotechnology research. Four representative motif structures of DNA self-assembly in literature were tested by the software for DNA sequence generation. A triple crossover triangle (TXT) motif and the corresponding 2-D array were designed by the software. The formation of the motif was assayed by polyacrylamide gel eletrophoresis and the 2-D array was observed in TEM. We distribute this software free of charge for academic research groups and non-profit organizations. The software and its operation manual are available in the following web address: http://ihome.ust.hk/similar to keymix/uniquimer.htm. It is the version 1.0 now. We will modify and perfect the software to be more efficient and user friendly in higher versions.
机译：我们开发了具有图形界面的计算机软件Uniquimer，该图形界面用于为DNA纳米技术研究生成各种DNA图案的从头DNA序列。通过用于DNA序列产生的软件测试了文献中DNA自组装的四个代表性基序结构。该软件设计了一个三重交叉三角形（TXT）图案和相应的2-D阵列。通过聚丙烯酰胺凝胶电泳分析基序的形成，并在TEM中观察到二维阵列。我们免费为学术研究团体和非营利组织分发此软件。该软件及其操作手册可从以下网址获得：http：//ihome.ust.hk/与keymix / uniquimer.htm类似。现在是1.0版。我们将修改并完善该软件，使其在更高版本中更加高效和用户友好。

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