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首页> 外文期刊>Journal of clinical anesthesia >Propofol-ketamine versus propofol-fentanyl for outpatient laparoscopy: comparison of postoperative nausea, emesis, analgesia, and recovery.
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Propofol-ketamine versus propofol-fentanyl for outpatient laparoscopy: comparison of postoperative nausea, emesis, analgesia, and recovery.

机译：丙泊酚氯胺酮与丙泊酚芬太尼用于门诊腹腔镜检查：术后恶心，呕吐，镇痛和恢复的比较。

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STUDY OBJECTIVE: To compare postoperative nausea, emesis, analgesia, and recovery between propofol-ketamine and propofol-fentanyl in outpatient laparoscopic tubal ligations with general anesthesia. STUDY DESIGN: Prospective, randomized, blinded study. SETTING: Tertiary-care women's hospital. PATIENTS: 120 ASA physical status I and II ambulatory patients scheduled for elective laparoscopic tubal ligation. INTERVENTIONS: Patients were randomized to two groups to receive either ketamine (1-1.5 mg/kg) or fentanyl (3-5 microg/kg). MEASUREMENTS: Measured variables included total dose of ketamine, fentanyl, propofol, and operating time. Vital signs, pain visual analog scale scores (VAS), nausea VAS, presence of emesis, treatment for nausea and vomiting, pruritus, sedation, and presence of dreaming were recorded on postanesthesia care unit (PACU) admission, PACU discharge, stepdown unit admission, and hospital discharge. Results are expressed as means +/- SD or medians and analyzed using t-test, Chi-square, orMann-Whitney (p < 0.05). MAIN RESULTS: No differences were noted with respect to propofol dose, operating times, pain or nausea VAS scores, emesis, treatment for nausea and vomiting, pruritus, and sedation on PACU admission, PACU discharge, stepdown unit admission, and hospital discharge. The ketamine group had a higher heart rate, required more pain medication, and had a higher frequency of dreaming on PACU admission than the fentanyl group. These differences became insignificant on PACU discharge. CONCLUSIONS: For outpatient laparoscopic tubal ligations with general anesthesia, propofol-ketamine does not improve postoperative nausea, emesis, analgesia or recovery compared with the propofol-fentanyl combination.
机译：目的：比较门诊全麻腹腔镜输卵管结扎术中丙泊酚-氯胺酮和丙泊酚-芬太尼的术后恶心，呕吐，镇痛和恢复情况。研究设计：前瞻性，随机，盲法研究。地点：三级护理妇女医院。患者：120名ASA身体状况I和II级非卧床患者，计划进行选择性腹腔镜输卵管结扎术。干预措施：将患者随机分为两组，分别接受氯胺酮（1-1.5 mg / kg）或芬太尼（3-5 microg / kg）。测量：测量变量包括氯胺酮，芬太尼，丙泊酚的总剂量和手术时间。在麻醉后护理病房（PACU）入院，PACU出院，降压病房入院时记录生命体征，疼痛视觉模拟量表评分（VAS），恶心VAS，呕吐，恶心和呕吐的治疗，瘙痒，镇静和做梦的情况。 ，并出院。结果表示为平均值+/- SD或中位数，并使用t检验，卡方或Mann-Whitney进行分析（p <0.05）。主要结果：在丙泊酚剂量，手术时间，疼痛或恶心的VAS评分，呕吐，恶心和呕吐的治疗，瘙痒和PACU入院时的镇静，PACU出院，降压单位入院和医院出院方面没有发现差异。与芬太尼组相比，氯胺酮组的心率更高，需要更多的止痛药，入PACU时做梦的频率更高。这些差异在PACU放电时变得无关紧要。结论：对于全麻的门诊腹腔镜输卵管结扎术，丙泊酚-氯胺酮与丙泊酚-芬太尼联合使用不会改善术后恶心，呕吐，镇痛或恢复。

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