...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of computer assisted tomography >Intensity-dependent Activation of the Primary Auditory Cortex in Functional Magnetic Resonance Imaging.
【24h】

Intensity-dependent Activation of the Primary Auditory Cortex in Functional Magnetic Resonance Imaging.

机译：功能磁共振成像中初级听觉皮层的强度依赖性激活。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSEThe purpose of this study was to investigate the activation patterns of the primary auditory cortex in response to varying intensities of pure tone stimuli.METHODA 1,000-Hz pure tone stimulus was delivered monaurally to the right ear of 12 normal-hearing right-handed volunteers in 20-second on-off cycles. Stimuli were applied at 20 and 50 dB hearing level (HL) above threshold in 12 subjects and at 0, 20, 40, and 50 dB HL above threshold in 6 subjects. Functional magnetic resonance imaging (fMRI) data were obtained using a 1.5-T scanner and echoplanar imaging. Activated pixels were identified in the transverse temporal gyrus (TTG) of both hemispheres in response to pure tone stimuli at each intensity level using cross-correlation analysis (0.6; P < 0.0001).RESULTSOf the 24 right and left TTGs imaged (n = 12), activation to pure tone stimuli at 20 and 50 dB HL above threshold was seen in 46% and 79% of TTGs, respectively, with bilateral hemispheric activation in 27% and 64% of subjects, respectively. The mean numbers of activated voxels were 4.0 and 13.0, respectively. Of the 12 right and left TTGs imaged at 0, 20, 40, and 50 dB HL above threshold, activation was seen in 33%, 42%, 58%, and 75% of TTGs, respectively. The mean numbers of activated voxels were 5.8, 3.2, 9.8, and 15.3, respectively. There was a nonsignificant trend toward contralateral (left) dominant TTG activation with increased tone intensity.CONCLUSIONOur results show an increased likelihood of TTG activation, increased TTG activation volume, and increased bilateral hemisphere TTG activation with increasing pure tone intensity. Our results suggest that the primary auditory cortex reflects or is directly involved in the central processing of sound intensity and that varying the intensity of even simple stimuli can alter the patterns of fMRI activation in auditory cortex.
机译：目的本研究的目的是研究对听觉皮层的不同刺激强度引起的听觉皮层的激活模式.METHODA 1,000Hz纯音刺激被单耳传递给12名正常听觉右手志愿者的右耳。 20秒的开关周期。在12名受试者中以高于阈值20和50 dB的听力水平（HL）施加刺激，在6名受试者中以高于阈值0、20、40和50 dB HL施加刺激。功能性磁共振成像（fMRI）数据是使用1.5-T扫描仪和回波平面成像获得的。使用互相关分析（0.6; P <0.0001），在每个强度水平上，响应于每个强度水平的纯音刺激，在两个半球的横向颞回（TTG）中识别出激活的像素。结果成像了24个左右的TTG（n = 12 ），分别在46％和79％的TTG中以高于阈值20和50 dB HL的水平激活纯音刺激，而在双侧半球激活中分别有27％和64％的受试者激活。激活体素的平均数分别为4.0和13.0。在阈值以上0、20、40和50 dB HL成像的12个左右TTG中，分别有33％，42％，58％和75％的TTG激活。激活体素的平均数分别为5.8、3.2、9.8和15.3。结论：结果显示，随着纯音强度的增加，对侧（左）占主导地位的TTG激活趋势不明显。结论我们的结果表明，TTG激活的可能性增加，TTG激活量增加，双侧半球TTG激活增加。我们的结果表明，初级听觉皮层反映或直接参与声音强度的中央处理，并且即使改变简单刺激的强度也可以改变听觉皮层中fMRI激活的模式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号