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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Comparison of tandem-in-space and tandem-in-time mass spectrometry in gas chromatography determination of pesticides: Application to simple and complex food samples
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Comparison of tandem-in-space and tandem-in-time mass spectrometry in gas chromatography determination of pesticides: Application to simple and complex food samples

机译：气相色谱法测定农药中的空间串联质谱和时间串联质谱的比较：在简单和复杂食品样品中的应用

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Gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) is one of the most powerful techniques in pesticide residue analysis. MS/MS can be conceived in two ways: tandem in space(e.g. triple quadrupole. QqQ) or in time (e.g. ion trap, IT). QqQ and IT are commonly interfaced to GC; however, there has not been any direct comparison between them in pesticide residue analysis so far. In the present work, the performance of GC coupled to these two analyzers (GC-QqQ-MS/MS and GC-IT-MS/MS) was studied and compared for pesticide residue analysis as well as its application in food analysis. The large Volume injection (LVI) technique together with programmed-temperature vaporization (PTV) was applied. For this purpose, 19 pesticides, including organochlorine and organophophorus pesticides and pyrethroids, were analyzed in both systems. Mass spectrometric data, performance characteristics (linearity, intra-day and inter-clay precision) and the influence of the matrix nature on the analysis of low concentrations were compared. The target compounds were analyzed in solvent and in two representative food matrices Such as cucumber (high water content) and egg (high fat content). MS data and intra-day precision were similar in QqQ and IT, whereas inter-day precision was significantly worse in Q(IQ. Linearity (expressed as determination coefficient, R-2 in the range 10-150 mu g L-1 was adequate in both systems: however, better R-2 values were obtained with the QqQ analyzer in high and low concentration ranges (1-50 and 1-750 mu g L-1, respectively). The influence of the matrix nature on the analysis of low concentrations of each analyzer was also evaluated. The QqQ and IT performance was similar in cucumber and solvent. However, QqQ provided better sensitivity in egg working in selected reaction monitoring (SRM). (C) 2008 Elsevier B.V. All rights reserved.
机译：气相色谱-串联质谱（GC-MS / MS）是农药残留分析中最强大的技术之一。 MS / MS可以通过两种方式来构想：在空间中串联（例如，三重四极杆QqQ）或在时间上串联（例如，离子阱，IT）。 QqQ和IT通常连接到GC。但是，到目前为止，在农药残留分析中还没有直接比较。在当前的工作中，研究了与这两种分析仪（GC-QqQ-MS / MS和GC-IT-MS / MS）结合使用的气相色谱仪的性能，并将其用于农药残留分析及其在食品分析中的应用。应用了大体积注入（LVI）技术和程序升温汽化（PTV）。为此，在两个系统中分析了19种农药，包括有机氯和有机磷农药以及拟除虫菊酯。比较了质谱数据，性能特征（线性，日内和粘土间精度）以及基质性质对低浓度分析的影响。在溶剂和两种代表性食品基质（如黄瓜（高水分含量）和鸡蛋（高脂肪含量））中分析目标化合物。 MS数据和日内精度在QqQ和IT中相似，而日间精度在Q（IQ。）差得多。线性（表示为测定​​系数，R-2在10-150μg L-1范围内足够在两种系统中：然而，使用QqQ分析仪在高和低浓度范围（分别为1-50和1-750μg L-1）中可获得更好的R-2值。在黄瓜和溶剂中，QqQ和IT性能相似，但是，QqQ在选定的反应监测（SRM）中对鸡蛋的工作具有更高的灵敏度（C）2008 Elsevier BV保留所有权利。

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