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首页> 外文期刊>Journal of clinical densitometry >Comparison of the relationship between bone marrow adipose tissue and volumetric bone mineral density in children and adults
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Comparison of the relationship between bone marrow adipose tissue and volumetric bone mineral density in children and adults

机译：儿童和成人骨髓脂肪组织与骨密度的关系

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摘要

Several large-scale studies have reported the presence of an inverse relationship between bone mineral density (BMD) and bone marrow adipose tissue (BMAT) in adults. We aim to determine if there is an inverse relationship between pelvic volumetric BMD (vBMD) and pelvic BMAT in children and to compare this relationship in children and adults. Pelvic BMAT and bone volume (BV) was evaluated in 181 healthy children (5-17. yr) and 495 healthy adults (≥18. yr) with whole-body magnetic resonance imaging (MRI). Pelvic vBMD was calculated using whole-body dual-energy X-ray absorptiometry to measure pelvic bone mineral content and MRI-measured BV. An inverse correlation was found between pelvic BMAT and pelvic vBMD in both children (r= -0.374, p<. 0.001) and adults (r= -0.650, p<. 0.001). In regression analysis with pelvic vBMD as the dependent variable and BMAT as the independent variable, being a child or adult neither significantly contribute to the pelvic BMD (p= 0.995) nor did its interaction with pelvic BMAT (p= 0.415). The inverse relationship observed between pelvic vBMD and pelvic BMAT in children extends previous findings that found the inverse relationship to exist in adults and provides further support for a reciprocal relationship between adipocytes and osteoblasts.
机译：几项大规模研究报告了成年人骨矿物质密度（BMD）与骨髓脂肪组织（BMAT）之间存在反比关系。我们的目的是确定儿童骨盆容积BMD（vBMD）与骨盆BMAT之间是否存在反比关系，并比较儿童和成人的这种关系。通过全身磁共振成像（MRI）评估了181名健康儿童（5-17岁）和495名健康成人（≥18岁）的骨盆BMAT和骨量（BV）。使用全身双能X射线吸收法测量骨盆vBMD，以测量骨盆骨矿物质含量和MRI测量的BV。在儿童（r = -0.374，p <。0.001）和成人（r = -0.650，p <。0.001）中，骨盆BMAT与骨盆vBMD之间存在反相关关系。在以骨盆vBMD为因变量，以BMAT为自变量的回归分析中，儿童或成人对骨盆BMD均无显着贡献（p = 0.995），也不与骨盆BMAT相互作用（p = 0.415）。儿童盆腔vBMD与盆腔BMAT之间的反比关系扩展了先前的发现，该发现发现这种反比关系存在于成年人中，并为脂肪细胞与成骨细胞之间的相互关系提供了进一步的支持。

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