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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging
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The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging

机译：靶向肿瘤的核壳结构负载DTX的PLGA @ Au纳米颗粒用于化学光热疗法和X射线成像

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In this study, an organic-inorganic hybrid nanocomposite was synthesized by deposition of Au onto the surface of docetaxel (DTX)-loaded poly (lactide-co-glycolide) (PLGA) nanoparticle cores to form the core-shell structured DTX-loaded PLGA@Au nanoparticles. The tumor targeting peptide, angiopep-2, was then introduced onto the gold nanoshell through Au-S bond, achieving drug delivery with active targeting capability. This novel system allowed combined chemotherapy and thermal therapy for cancer, resulting from DTX and gold nanoshell. The formation of tumor-targeting gold nanoshell surrounding PLGA nanocore, designated as ANG/GS/PLGA/DTX NPs, was confirmed by its surface plasmon resonance (SPR) band in the UV-Vis spectrum and by a transmission electron microscope (TEM). The release profiles of DTX from this system showed strong dependence on near-infrared (NIR) laser. Compared with DTX alone, the ANG/GS/PLGA/DTX NPs afforded much higher anti-tumor efficiency without obvious toxic effects. Besides, it also showed potential X-ray imaging ability. These results demonstrated that the tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles could be used as a multifunctional nanomaterial system with NIR-triggered drug-releasing properties for tumor-targeted chemo-photothermal therapy and theranostics. (C) 2015 Elsevier B.V. All rights reserved.
机译：在这项研究中，有机-无机杂化纳米复合材料是通过将Au沉积在负载多西他赛（DTX）的聚（丙交酯-乙交酯）（PLGA）纳米颗粒核的表面上而形成的，以形成核-壳结构负载DTX @金纳米颗粒。然后通过Au-S键将肿瘤靶向肽angiopep-2引入到金纳米壳上，从而实现具有主动靶向能力的药物递送。这种新颖的系统允许将DTX和金纳米壳制成的癌症进行化学疗法和热疗法相结合。围绕着PLGA纳米核的靶向肿瘤的金纳米壳（称为ANG / GS / PLGA / DTX NPs）的形成通过其在UV-Vis光谱中的表面等离振子共振（SPR）谱带和透射电子显微镜（TEM）得以证实。 DTX从该系统的释放曲线显示出对近红外（NIR）激光的强烈依赖性。与单独的DTX相比，ANG / GS / PLGA / DTX NP具有更高的抗肿瘤效率，而没有明显的毒性作用。此外，它还显示出潜在的X射线成像能力。这些结果表明，靶向肿瘤的核壳结构负载DTX的PLGA @ Au纳米颗粒可以用作具有NIR触发释药特性的多功能纳米材料系统，用于靶向肿瘤的化学光热疗法和治疗学。 （C）2015 Elsevier B.V.保留所有权利。

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