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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Delivery strategies to control inflammatory response: Modulating M1-M2 polarization in tissue engineering applications
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Delivery strategies to control inflammatory response: Modulating M1-M2 polarization in tissue engineering applications

机译：控制炎症反应的递送策略：在组织工程应用中调节M1-M2极化

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摘要

Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflammatory). In tissue engineering scenarios, after implantation of any device, it is desirable to exercise control on this M1-M2 progression and to ensure a timely and smooth transition from the inflammatory to the healing stage. In this review, we briefly introduce the current state of knowledge regarding macrophage function and nomenclature. Next, we discuss the use of controlled release strategies to tune the balance between the M1 and M2 phenotypes in the context of tissue engineering applications. We discuss recent literature related to the release of anti-inflammatory molecules (including nucleic acids) and the sequential release of cytokines to promote a timely M1-M2 shift. In addition, we describe the use of macrophages as controlled release agents upon stimulation by physical and/or mechanical cues provided by scaffolds. Moreover, we discuss current and future applications of "smart" implantable scaffolds capable of controlling the cascade of biochemical events related to healing and vascularization. Finally, we provide our opinion on the current challenges and the future research directions to improve our understanding of the M1-M2 macrophage balance and properly exploit it in tissue engineering and regenerative medicine applications. (C) 2016 Elsevier B.V. All rights reserved.
机译：巨噬细胞是包括组织稳态在内的许多生理情况下的关键角色。响应损伤，通常巨噬细胞亚群之间的平衡从M1表型（促炎性）转变为M2表型（抗炎性）。在组织工程中，在植入任何装置之后，都需要对这种M1-M2进程进行控制，并确保从炎症阶段到愈合阶段的及时，平稳过渡。在这篇综述中，我们简要介绍了有关巨噬细胞功能和术语的知识的现状。接下来，我们讨论在组织工程应用中使用控释策略来调节M1和M2表型之间的平衡。我们讨论了与抗炎分子（包括核酸）的释放和细胞因子的顺序释放有关的最新文献，以促进及时的M1-M2转移。另外，我们描述了通过支架提供的物理和/或机械提示刺激后巨噬细胞作为控释剂的用途。此外，我们讨论了能够控制与愈合和血管形成有关的生化事件的级联的“智能”植入式支架的当前和未来应用。最后，我们对当前的挑战和未来的研究方向提出了自己的见解，以增进我们对M1-M2巨噬细胞平衡的了解，并在组织工程和再生医学应用中适当地利用它。 （C）2016 Elsevier B.V.保留所有权利。

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