• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications
【24h】

Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications

机译：使用药物输送系统进行超声触发的药物输送，用于癌症治疗：从理论考虑到实际应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ultrasound-triggered drug delivery is now becoming a mature technology with first patients enrolling in clinical trials. Having a clear overview of the field is complicated as it mixes ultrasound physics and biological effects, particle formulation, and pharmacokinetics and biodistribution. The scope of this review is to move from basics to the latest developments of combined techniques using ultrasound for triggering drug release. Generalities on ultrasound are first given to better understand the parameters on which the clinician can operate to modulate the amount of delivered energy. Ultrasound effects on biological tissues such as thermal effects, mechanical effects and radiation forces are also presented. The second part of this review deals with the combination of ultrasound and drug delivery systems to enhance the efficacy of current cancer treatment. The in vivo behavior of drug delivery systems and how ultrasounds can be combined to improve treatment efficacy are detailed. The example of ThermoDox (R), a new formulation of thermosensitive liposomes undergoing a phase III clinical trial, is particularly discussed on the basis of the available clinical data. Through the present article, researchers will be able to better grasp the different levels of complexity when designing an efficient formulation to be combined with ultrasound. (C) 2016 Elsevier B.V. All rights reserved.
机译：超声触发的药物输送现已成为一项成熟的技术，第一批患者参加了临床试验。对该领域有一个清晰的概述是很复杂的，因为它将超声物理和生物学效应，颗粒配方以及药代动力学和生物分布结合在一起。这篇综述的范围是从基础到使用超声触发药物释放的联合技术的最新发展。首先给出超声的一般性，以更好地理解临床医生可以操作以调节传递的能量的参数。还介绍了超声波对生物组织的影响，例如热效应，机械效应和辐射力。这篇综述的第二部分涉及超声和药物输送系统的组合，以增强当前癌症治疗的功效。详细介绍了药物输送系统的体内行为以及如何组合超声以改善治疗效果。根据可得的临床数据，特别讨论了ThermoDox（R）的示例，它是经过III期临床试验的热敏脂质体的新制剂。通过本文，研究人员在设计与超声结合的有效配方时将能够更好地把握不同程度的复杂性。 （C）2016 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号