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Immunity, Pathophysiology, and Diagnosis of Equine Protozoal Myeloencephalitis

机译:马原生动物脊髓性脑炎的免疫,病理生理学和诊断

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Our understanding of the pathophysiology of equine protozoal myeloencephalitis CEPM) remains incomplete, yet the development of clinical models, engineered mice, and molecular techniques have contributed markedly to our knowledge of this illness. Research confirms that the most important mediator of immunity to EPM is interferon-gamma, while the humoral immune system also contributes via inactivation of specific protozoal surface proteins. Diagnosis of EPM remains a clinical challenge, yet careful consideration of the clinical examination, coupled with ancillary diagnostic tests such as the cerebrospinal fluid evaluation, and various immunodiagnostic tests (Western blot, indirect fluorescent antibody) provide support for a clinical diagnosis.
机译:我们对马原生动物脊髓性脑炎(PMPM)的病理生理学的了解仍然不完整,但是临床模型,工程小鼠和分子技术的发展为我们对这种疾病的了解做出了显着贡献。研究证实,对EPM免疫力最重要的介质是干扰素-γ,而体液免疫系统也通过灭活特定的原生动物表面蛋白而发挥作用。 EPM的诊断仍然是一项临床挑战,但要仔细考虑临床检查,并辅以诸如脑脊液评估之类的辅助诊断测试,以及各种免疫诊断测试(Western blot,间接荧光抗体)为临床诊断提供支持。

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