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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols
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Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols

机译：糖醇相变制得的速崩片剂的评价

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摘要

The aim of the present study was to assess the properties of rapidly disintegrating (RD) tablets manufactured by the phase transition method. R-D tablets were produced by compressing powder containing erythritol (melting point: 122 degrees C) and xylitol (melting point: 93-95 degrees C), and then heating at about 93 degrees C for 15 min. The hardness and oral disintegration time of the heated tablets increased with an increase of the xylitol content. These results suggested that the heating process and xylitol content might influence the properties of RD tablets. Then we evaluated the physicochemical properties of the RD tablets, including the median pore size, crystallinity, hardness, and oral disintegration time of tablets made with and without heating. After heating, the median pore size of the tablets was increased and tablet hardness was also increased. The increase of tablet hardness with heating and storage did not depend on the crystal state of the lower melting point sugar alcohol. It is concluded that a combination of low and high melting point sugar alcohols, as well as a phase transition in the manufacturing process, are important for making RD tablets without any special apparatus. (c) 2005 Elsevier B.V All rights reserved.
机译：本研究的目的是评估通过相变法制造的快速崩解（RD）片剂的性能。通过压缩含有赤藓糖醇（熔点：122℃）和木糖醇（熔点：93-95℃）的粉末，然后在约93℃下加热15分钟来制备R-D片剂。随着木糖醇含量的增加，加热的片剂的硬度和口腔崩解时间增加。这些结果表明，加热过程和木糖醇含量可能会影响RD片剂的性能。然后，我们评估了RD片剂的理化性质，包括加热和不加热的片剂的中值孔径，结晶度，硬度和口腔崩解时间。加热后，片剂的中值孔径增加，片剂硬度也增加。随着加热和储存，片剂硬度的增加并不取决于低熔点糖醇的晶体状态。结论是，低熔点糖醇和高熔点糖醇的组合以及制造过程中的相变对于无需任何特殊设备即可制备RD片剂很重要。 （c）2005 Elsevier B.V保留所有权利。

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