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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Nano particle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
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Nano particle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance

机译：纳米粒子介导的化学疗法和光动力疗法相结合，克服了肿瘤的耐药性

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摘要

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their intracellular site of action. In this study,we investigated the anticancer efficacy of doxorubicin in combination with photodynamic therapy using methylene blue in a drug-resistant mouse tumor model. Surfactant-polymer hybrid nanoparticles formulated using an anionic surfactant, Aerosol-OT (TM) (AOT), and a naturally occurring polysaccharide polymer. sodium alginate, were used for synchronized delivery of the two drugs. Balb/c mice bearing syngeneic JC tumors (mammary adenocarcinoma) were used as a drug-resistant tumor model. Nanoparticle-mediated combination therapy significantly inhibited tumor growth and improved animal survival. Nanoparticle-mediated combination treatment resulted in enhanced tumor accumulation of both doxorubicin and methylene blue, significant inhibition of tumor cell proliferation, and increased induction of apoptosis. These data suggest that nanoparticle-mediated combination chemotherapy and photodynamic therapy using doxorubicin and methylene blue has significant therapeutic potential against drug-resistant tumors.
机译：肿瘤耐药性大大限制了化学疗法在临床上的成功。肿瘤细胞利用多种机制来防止抗癌药在其细胞内作用位点积聚。在这项研究中，我们研究了阿霉素联合亚甲基蓝光动力学疗法在耐药小鼠肿瘤模型中的抗癌作用。使用阴离子表面活性剂，Aerosol-OT（TM）（AOT）和天然多糖聚合物配制的表面活性剂-聚合物杂化纳米颗粒。海藻酸钠用于同步递送两种药物。携带同基因JC肿瘤（乳腺腺癌）的Balb / c小鼠被用作耐药性肿瘤模型。纳米粒子介导的联合疗法可显着抑制肿瘤生长并改善动物存活率。纳米粒子介导的联合治疗导致阿霉素和亚甲蓝的肿瘤积累增强，肿瘤细胞增殖得到显着抑制，凋亡诱导增加。这些数据表明使用阿霉素和亚甲基蓝的纳米粒子介导的联合化学疗法和光动力疗法对耐药性肿瘤具有显着的治疗潜力。

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