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Targeted delivery of miRNA therapeutics for cardiovascular diseases: Opportunities and challenges

机译：针对心血管疾病的miRNA治疗药物的靶向交付：机遇与挑战

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摘要

Dysregulation of miRNA expression has been associated with many cardiovascular diseases in animal models, as well as in patients. In the present review, we summarize recent findings on the role of miRNAs in cardiovascular diseases and discuss the opportunities, possibilities and challenges of using miRNAs as future therapeutic targets. Furthermore, we focus on the different approaches that can be used to deliver these newly developed miRNA therapeutics to their sites of action. Since siRNAs are structurally homologous with the miRNA therapeutics, important lessons learned from siRNA delivery strategies are discussed that might be applicable to targeted delivery of miRNA therapeutics, thereby reducing costs and potential side effects, and improving efficacy.
机译：在动物模型以及患者中，miRNA表达失调与许多心血管疾病有关。在本综述中，我们总结了关于miRNA在心血管疾病中的作用的最新发现，并讨论了使用miRNA作为未来治疗靶点的机遇，可能性和挑战。此外，我们关注可用于将这些新开发的miRNA治疗剂传递至其作用部位的不同方法。由于siRNA在结构上与miRNA治疗剂同源，因此讨论了从siRNA输送策略中学到的重要经验，这些经验教训可能适用于miRNA治疗剂的靶向输送，从而降低了成本和潜在的副作用，并提高了疗效。

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