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首页> 外文期刊>Journal of Controlled Release: Official Journal of the Controlled Release Society >Induction of potent CD8 ~+ T cell responses through the delivery of subunit protein vaccines to skin antigen-presenting cells using densely packed microprojection arrays
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Induction of potent CD8 ~+ T cell responses through the delivery of subunit protein vaccines to skin antigen-presenting cells using densely packed microprojection arrays

机译：通过使用致密堆积的微突出物阵列将亚基蛋白疫苗递送至皮肤抗原呈递细胞，诱导有效的CD8〜+ T细胞反应

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The generation of both antibody and CD8 ~+ T cell responses against pathogens is considered important for many advanced vaccines for diseases including tuberculosis, HIV and malaria. However, most current vaccines are delivered into muscle by the needle and syringe method and induce protection via humoral (antibody) immune responses. In this paper, we test the hypothesis that delivering a model subunit protein antigen (ovalbumin) to the skin's abundant immune cell population using a densely packed microprojection array (Nanopatch) enhances CD8 ~+ T cell responses. We found that the Nanopatch significantly enhanced the CD8 ~+ T cell responses when compared to intramuscular delivery of both antigen-only and adjuvanted cases (Quil-A and CpG; separately). To our knowledge, this is the first published study demonstrating significantly improved CD8 ~+ T cell responses achieved by delivering subunit vaccines to the skin's abundant immune cell population. Successfully replicating these findings in humans could significantly advance the reach of vaccines.
机译：对于病原体的许多先进疫苗，包括结核病，HIV和疟疾，抗病菌的抗体和CD8 + T细胞反应的产生被认为是重要的。但是，大多数当前的疫苗是通过针头和注射器的方法递送到肌肉中的，并通过体液（抗体）免疫反应诱导保护作用。在本文中，我们测试了以下假设：使用密集包装的微突出物阵列（Nanopatch）将模型亚基蛋白抗原（卵清蛋白）传递至皮肤的大量免疫细胞群体会增强CD8〜+ T细胞反应。我们发现，与仅抗原性和佐剂性病例（Quil-A和CpG;分别）的肌肉内递送相比，Nanopatch显着增强了CD8〜+ T细胞应答。据我们所知，这是第一个发表的研究，证明通过向皮肤的大量免疫细胞群中运送亚单位疫苗可以显着改善CD8〜+ T细胞反应。在人类中成功复制这些发现可能会大大促进疫苗的普及。

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