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首页> 外文期刊>Journal of drugs in dermatology: JDD >A new body moisturizer increases skin hydration and improves atopic dermatitis symptoms among children and adults.
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A new body moisturizer increases skin hydration and improves atopic dermatitis symptoms among children and adults.

机译：一种新的身体保湿剂可增加儿童和成人的皮肤水分，改善特应性皮炎症状。

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摘要

Moisturizers result in an increase of skin hydration and restoration of the skin barrier function and play a prominent role in the longterm management of atopic dermatitis (AD). Cetaphil RestoradermTM Moisturizer (CRM) contains novel ingredients specifically designed for AD, and its effects on skin hydration, skin barrier function and signs of AD were assessed in four studies, three of which were evaluator-blinded, randomized and intra-individual comparison trials. A single application of CRM induced significantly greater hydration than the untreated control for at least 24 hours (P is less than 0.001). After the skin was disrupted with 0.5% sodium dodecyl sulfate (SDS), applications of CRM led to a more rapid restoration of skin barrier function and maintained significantly greater skin hydration compared to the untreated control (both P is less than 0.05). After four weeks of twice-daily CRM application among subjects with a history of AD, a significant decrease of itching/stinging scores compared to baseline was reported, as well as an improvement in the quality-of- life and a high level of satisfaction regarding the product. When CRM was used as an adjunctive treatment with topical steroid for four weeks among subjects with mild-to-moderate AD, a more rapid decrease of overall disease severity was observed on days 7, 14 and 21 by the blinded investigator (P is less than 0.05), compared to steroid treatment alone. In summary, CRM is suitable for the specific needs of patients with AD and can be used either alone for long-term management or in adjunction with traditional treatment for both short and long-term disease control.
机译：保湿剂可增加皮肤的水合作用并恢复其皮肤屏障功能，并在特应性皮炎（AD）的长期管理中发挥重要作用。 Cetaphil RestoradermTM保湿剂（CRM）包含专为AD设计的新型成分，并且在四项研究中评估了其对皮肤水分，皮肤屏障功能和AD征象的影响，其中三项是评估者盲法，随机和个体内部比较试验。至少在24小时内，单次使用CRM会比未处理的对照引起更大的水合作用（P小于0.001）。用0.5％的十二烷基硫酸钠（SDS）破坏皮肤后，与未处理的对照组相比，CRM的使用可更快恢复皮肤屏障功能并保持明显更高的皮肤水合作用（两者均小于0.05）。据报道，有AD史的受试者每天两次接受两次CRM，与基线相比，瘙痒/刺痛得分显着降低，生活质量得到改善，并且满意度较高产品。在患有轻度至中度AD的受试者中，当CRM用作局部类固醇的辅助治疗达4周时，盲人研究人员在第7、14和21天观察到总体疾病严重程度的下降更为迅速（P小于0.05），与单独使用类固醇治疗相比。总之，CRM适用于AD患者的特定需求，既可以单独用于长期管理，也可以与传统治疗相结合用于短期和长期疾病控制。

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