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首页> 外文期刊>The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry >Salivary and serum insulin-like growth factor (IGF-1) assays in anorexic patients
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Salivary and serum insulin-like growth factor (IGF-1) assays in anorexic patients

机译：厌食症患者的唾液和血清胰岛素样生长因子（IGF-1）测定

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Objectives. The purpose of this study was to measure the salivary and serum free IGF-1 concentration of patients with anorexia nervosa (AN) in comparison to an average population. Methods. A controlled clinical trial was designed for an age- and gender-matched group of 121 AN patients and 77 healthy individuals. A clinical examination was made and blood and salivary samples were taken during the acute stage of AN (BMI < 15 kg/m(2)) in the first week of hospitalization. An enzyme immunoassay (ELISA) suitable for measuring free IGF-1 was used. Results. Anorexic patients had significant reductions in salivary unstimulated flow rate (UFR), pH and free IGF-1 levels in their saliva and serum. Significant correlations between serum IGF-1 and BMI; salivary IGF-1 and UFR and pH were detected. Conclusions. Salivary and serum IGF-1 analyses appear to be a reliable biochemical indicator of malnutrition in AN patients. Measurement of salivary IGF-1 levels would allow new perspectives in monitoring AN in its early stages.
机译：目标。这项研究的目的是测量与平均人群相比神经性厌食症（AN）患者唾液和血清中IGF-1的浓度。方法。为121名AN患者和77名健康个体的年龄和性别匹配组设计了一项对照临床试验。在住院的第一周，在AN的急性期（BMI <15 kg / m（2））进行了临床检查并采集了血液和唾液样本。使用适合于测量游离IGF-1的酶免疫测定法（ELISA）。结果。厌食症患者的唾液和血清唾液非刺激性流速（UFR），pH和游离IGF-1水平显着降低。血清IGF-1与BMI之间的显着相关性;检测唾液中的IGF-1，UFR和pH。结论。唾液和血清IGF-1分析似乎是AN患者营养不良的可靠生化指标。唾液中IGF-1水平的测量将为早期监测AN提供新的观点。

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