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首页> 外文期刊>Journal of drugs in dermatology: JDD >The Role of Benzoyl Peroxide in the New Treatment Paradigm for Acne
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The Role of Benzoyl Peroxide in the New Treatment Paradigm for Acne

机译：过氧化苯甲酰在痤疮治疗新范例中的作用

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Bacterial resistance became a true clinical concern for dermatologists in the 1980s, when the first reports emerged of the resistance of Propionibacterium acnes to oral antibiotics. Subsequent studies have documented acne treatment failure associated with resistance to topical antibiotics. Beyond dermatology practice, antibiotic resistance has now become recognized as a worldwide health concern. In contrast to antibiotics commonly used in the treatment of acne, benzoyl peroxide (BP)'s mechanism of action is different. Benzoyl peroxide is a bactericidal agent. Combining BP with a topical antibiotic in a stable formulation has been proven in clinical trials to reduce total P acnes count by 99.7% after 1 week of therapy, eliminating both susceptible and resistant strains of P acnes. However, we have recently noticed BP's benefits as monotherapy in the treatment of acne. Benzoyl peroxide works rapidly on P acnes without causing antibiotic resistance. Hence, we may have to reconsider the role of topical antibiotics such as clindamycin in the treatment paradigm of acne vulgaris.
机译：当痤疮丙酸杆菌对口服抗生素的耐药性首次报道出现时，细菌耐药性在1980年代引起了皮肤科医生的真正临床关注。随后的研究表明痤疮治疗失败与对局部抗生素的耐药性有关。除皮肤病学实践外，抗生素耐药性现在已成为公认的全球健康问题。与通常用于治疗痤疮的抗生素相反，过氧化苯甲酰（BP）的作用机理不同。过氧化苯甲酰是杀菌剂。在临床试验中已证明，将BP与局部抗生素组合以稳定的制剂治疗1周后可将总痤疮计数减少99.7％，从而消除了易感和耐药的痤疮菌株。但是，我们最近注意到BP作为治疗痤疮的单一疗法的益处。过氧化苯甲酰可快速作用于痤疮，而不会引起抗生素耐药性。因此，我们可能必须重新考虑局部用抗生素（如克林霉素）在寻常性痤疮的治疗中的作用。

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