Microneedling Prior to Levulan PDT for the Treatment of Actinic Keratoses: A Split-Face, Blinded Trial

Spencer James M.; Freeman Scott A.

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Microneedling Prior to Levulan PDT for the Treatment of Actinic Keratoses: A Split-Face, Blinded Trial

机译：Levulan PDT之前的微针治疗光化性角化病的方法：分面盲试验

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Introduction: Photodynamic Therapy (PDT) with topical Levulan is an approved and efficacious method for treating actinic keratoses. This therapy depends on the ability of the Levulan (delta amino levulinic acid) to penetrate the stratum corneum and enter the cells of the epidermis. Microneedling is an increasing popular cosmetic therapy in which an array of tiny needles is used to make holes in the epidermis and presumably induce a wound healing cascade that leads to cosmetic improvement of the skin. We were interested to know if prior microneedling would enhance the penetration of topical Levulan and thus enhance the PDT treatment, and if a cosmetic improvement beyond the PDT alone would be seen when it is used in conjunction with microneedling.

机译：简介：外用Levulan的光动力疗法（PDT）是一种公认的行之有效的治疗光化性角化病的方法。此疗法取决于Levulan（δ氨基乙酰丙酸）穿透角质层并进入表皮细胞的能力。微针是一种越来越流行的美容疗法，其中使用一排细针在表皮上打孔，并可能引起伤口愈合，从而改善皮肤的美容效果。我们很想知道以前的微针是否会增强局部Levulan的渗透性，从而增强PDT的治疗效果，以及将其与微针一起使用是否会获得超过PDT的美容效果。

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《Journal of drugs in dermatology: JDD》 |2016年第9期|共3页
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Spencer James M.; Freeman Scott A.;
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正文语种 eng
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1. Microneedling Prior to Levulan PDT for the Treatment of Actinic Keratoses: A Split-Face, Blinded Trial [J] . Spencer James M., Freeman Scott A. Journal of drugs in dermatology: JDD . 2016,第9期

机译：Levulan PDT之前的微针治疗光化性角化病的方法：分面盲试验
2. Treatment of actinic keratoses on the dorsum of the hands: ALA-PDT versus diclofenac 3% gel followed by ALA-PDT. A placebo-controlled, double-blind, pilot study. [J] . Van der Geer S, Krekels GA The Journal of dermatological treatment . 2009,第5期

机译：手背光化性角化病的治疗：ALA-PDT对比3％双氯芬酸凝胶，然后进行ALA-PDT。安慰剂对照的双盲试验研究。
3. Results of an investigator-initiated single-blind split-face comparison of photodynamic therapy and 5% imiquimod cream for the treatment of actinic keratoses [J] . HadleyJ., Tristani-FirouziP., HullC., Dermatologic surgery . 2012,第5期

机译：研究人员启动的光动力疗法与5％咪喹莫特乳膏治疗光化性角化病的单盲双脸比较结果
4. Handheld dual fluorescence and reflectance spectroscopy system for monitoring topical low dose ALA-PDT of actinic keratoses (AK) [C] . Ivan Charamisinau, Kenneth Keymel, William Potter, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV; Progress in Biomedical Optics and Imaging; vol.7 no.25 . 2006

机译：手持式双重荧光和反射光谱系统，用于监测光化性角化病（AK）的局部低剂量ALA-PDT
5. A split-face comparison of photodynamic therapy using blue light versus intense pulsed light for treatment of facial actinic keratosis. [D] . Jungcharoensukying, Ploypailin. 2010

机译：使用蓝光与强脉冲光治疗面部光化性角化病的光动力疗法的分面比较。
6. A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol® cream for the treatment of actinic keratoses [O] . Malkanthi Evans, Douglas Kalman, Patricia Alvarez, 1979

机译：一项评估Dermytol®霜用于治疗光化性角化病的随机，双盲，安慰剂对照临床试验
7. 284 An intrapatient, bilaterally-controlled clinical trial comparing a sequential combination of topical 5-fluorouracil (5-FU) and photodynamic therapy (PDT), versus PDT alone, in photodamaged patients and organ transplant recipients with actinic keratoses [O] . E.V. Maytin, M. Riha, S. Anand, 2016

机译：284对体内对照的局部控制临床试验比较了局部5-氟尿嘧啶（5-FU）和光动力治疗（PDT）的顺序组合，单独对PDT，具有光电型患者和器官移植受体，具有光化角膜

Microneedling Prior to Levulan PDT for the Treatment of Actinic Keratoses: A Split-Face, Blinded Trial

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