Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.

Matsuda T; Aoki T; Ohgiya T; Koshi T; Ohkuchi M; Shigyo H

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Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.

机译：新型哒嗪衍生物的合成和生物活性：白介素1β（IL-1beta）生产的抑制剂。

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New pyridazine derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described.

机译：制备了新的哒嗪衍生物，并评估了它们抑制IL-1β产生的能力。在脂多糖（LPS）刺激的HL-60细胞中，某些化合物对IL-1β的产生具有抑制作用。描述了这些化合物的合成和结构-活性关系。

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《Bioorganic and Medicinal Chemistry Letters》 |2001年第17期|共4页
作者
Matsuda T; Aoki T; Ohgiya T; Koshi T; Ohkuchi M; Shigyo H;
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正文语种 eng
中图分类药学;生物化学;
关键词
pyridazine; derivatives; Production;

机译：哒嗪;衍生物;生产;

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专利

1. Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production. [J] . Matsuda T, Aoki T, Ohgiya T, Bioorganic and Medicinal Chemistry Letters . 2001,第17期

机译：新型哒嗪衍生物的合成和生物活性：白介素1β（IL-1beta）生产的抑制剂。
2. Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages. [J] . Blonska M, Czuba ZP, Krol W Scandinavian journal of immunology. . 2003,第2期

机译：黄酮衍生物对刺激的RAW 264.7巨噬细胞中白介素-1β（IL-1beta）mRNA表达和IL-1beta蛋白质合成的影响。
3. Interleukin-1 beta (IL-1beta) induces tumor necrosis factor alpha (TNF-alpha) expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation. [J] . Ledesma E, Martinez I, Cordova Y, Cytokine . 2004,第2期

机译：白介素-1 beta（IL-1beta）诱导小鼠骨髓多能细胞系32D cl3上的肿瘤坏死因子alpha（TNF-alpha）表达，并抑制其增殖。
4. IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: Effect of Rhein [C] . N.G. de Isla, J.W. Yang, C. Huselstei International Symposium on Mechanobiology of Cartilage and Chondrocyte . 2006

机译：通过3D显微镜和流式细胞术分析的软骨细胞的IL-1Beta合成：莱茵素的作用
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7. Effect of Flavone Derivatives on Interleukin-1beta (IL-1beta) mRNA Expression and IL-1beta Protein Synthesis in Stimulated RAW 264.7 Macrophages [O] . M. Blonska, Z. P. Czuba, W. Krol 2003

机译：黄酮衍生物对白细胞介素-1Beta（IL-1Beta）mRNA表达和IL-1Beta蛋白合成刺激的原料264.7巨噬细胞的影响

Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.

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