...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cutaneous pathology >Protein expression of melanocyte growth factors (bFGF, SCF) and their receptors (FGFR-1, c-kit) in nevi and melanoma.
【24h】

Protein expression of melanocyte growth factors (bFGF, SCF) and their receptors (FGFR-1, c-kit) in nevi and melanoma.

机译：痣和黑色素瘤中黑色素细胞生长因子（bFGF，SCF）及其受体（FGFR-1，c-kit）的蛋白表达。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Basic fibroblast growth factor (bFGF) and stem cell factor (SCF) are essential growth factors for melanocytes which carry the receptors FGFR-1 for bFGF and c-kit for SCF. Because both factors may be involved in melanoma development, the expression of bFGF/FGFR-1 and SCF/c-kit was investigated in melanocytic tumors of different progression stages. METHODS: Fifty primary melanomas and 44 melanocytic nevi were analyzed for the expression of SCF, c-kit, bFGF, and FGFR-1 by immunohistochemistry. RESULTS: In melanoma, SCF and c-kit were expressed in 76 and 84%, respectively, and coexpressed in 66%. bFGF and FGFR-1 were expressed in 45 and 86%, respectively, and coexpressed in 46%. In melanocytic nevi, SCF was expressed in 23% and c-kit in 70% while coexpression was more common in dysplastic (39%) than non-dysplastic subtypes (8%). bFGF and FGFR-1 were expressed in 55 and 67%, respectively, while coexpression was found in 47% but varied considerably between different histological subtypes. CONCLUSIONS: SCF and c-kit were frequently expressed by melanomas and dysplastic nevi suggesting an autocrine growth mechanism as described for bFGF. In both nevi and melanoma, c-kit was almost exclusively found in the epidermis while bFGF was more common in the dermis. Thus the growth factor/receptor expression seems to depend on the cutaneous localization of the melanocytic tumors.
机译：背景：碱性成纤维细胞生长因子（bFGF）和干细胞因子（SCF）是黑色素细胞必不可少的生长因子，这些黑色素细胞带有bFGF的FGFR-1受体和SCF的c-kit。由于这两个因素都可能与黑色素瘤的发生有关，因此在不同进展阶段的黑素细胞瘤中研究了bFGF / FGFR-1和SCF / c-kit的表达。方法：采用免疫组织化学方法分析50例原发性黑素瘤和44例黑素细胞痣的表达。结果：在黑色素瘤中，SCF和c-kit分别表达76％和84％，并共表达66％。 bFGF和FGFR-1分别以45％和86％表达，并以46％共表达。在黑素细胞痣中，SCF的表达率为23％，c-kit的表达率为70％，而发育异常的亚型（39％）比非发育异常的亚型（8％）更常见。 bFGF和FGFR-1的表达分别为55％和67％，而共表达的表达为47％，但在不同的组织学亚型之间差异很大。结论：SCF和c-kit经常由黑色素瘤和发育不良痣表达，提示bFGF有自分泌生长机制。在痣和黑色素瘤中，c-kit几乎只在表皮中发现，而bFGF在真皮中更常见。因此，生长因子/受体表达似乎取决于黑素细胞瘤的皮肤定位。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号