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首页> 外文期刊>Journal of cutaneous pathology >A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation.
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A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation.

机译:一例原发性爱泼斯坦-巴尔病毒相关的皮肤弥漫性大B细胞淋巴瘤与医源性或内源性免疫失调无关。

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摘要

Cutaneous Epstein-Barr virus (EBV)-associated B-cell lymphoma (EBVBL) in non-immunocompromised patients is very rare. Here, we report a case of cutaneous EBVBL in a 72-year-old Japanese woman without any signs of immunosuppression. She showed repeated high fever and skin eruptions on the face, limbs and palms. Histological diagnosis was diffuse large B-cell lymphoma. EBV infection was detected by in situ hybridization and Southern blotting. Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern.
机译:在非免疫功能低下的患者中,皮肤爱泼斯坦-巴尔病毒(EBV)相关的B细胞淋巴瘤(EBVBL)非常罕见。在此,我们报告了一名72岁的日本女性皮肤EBVBL的病例,该病例没有任何免疫抑制的迹象。她表现出反复发高烧,面部,四肢和手掌出现皮肤喷发。组织学诊断为弥漫性大B细胞淋巴瘤。通过原位杂交和Southern印迹检测EBV感染。病毒蛋白免疫染色显示该患者的潜伏膜蛋白1(LMP-1)阳性,而爱泼斯坦-巴尔病毒核抗原1(EBNA-2)阴性,表明II型潜伏期EBV感染模式。

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