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首页> 外文期刊>Journal of cutaneous pathology >Pitfalls in prognostic factor studies.
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Pitfalls in prognostic factor studies.

机译：预后因素研究中的陷阱。

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In their interesting study, Janisson-Dargaud et al. investigated the association of epithelial growth factor receptor (EGFR) expression with the risk of recurrences of basal cell carcinomas (BCCs). The authors compared the proportion of patients with more or less than 50% of EGFR-stained tumor cells between groups with and without recurrences, using Fisher's exact test. The conclusion was that aneuploidy, but not Ki-67 or EGFR expression, is associated with recurrences in BGC.We would like to discuss some methodological aspects of this investigation: the percentage of ERGF-positive cells was dichotomized. The categorization of variables that are initially measured on a continuum is a frequently used procedure in surgical pathology, especially for the documentation of immunohistochemistry, as recent issues of this journal demonstrate. Although this procedure may be useful for clinical decision making, or illustration purposes, it may negatively affect statistical evaluations. Usually there is no standardization for the cutoff values of immunohistochemical data. In many investigations, the choice of the cutoff level is not justified at all. Therefore, results from different publications can only hardly be compared.
机译：Janisson-Dargaud等人在他们有趣的研究中。研究了上皮生长因子受体（EGFR）表达与基底细胞癌（BCC）复发风险的关系。作者使用Fisher精确检验比较了有或无复发组之间EGFR染色肿瘤细胞多于或少于50％的患者比例。结论是非整倍性与Ki-67或EGFR表达无关，但与BGC的复发有关。最初在连续体上测量的变量的分类是外科病理学中经常使用的程序，尤其是对于免疫组织化学的文献，正如该期刊的最新报道所证明的那样。尽管此过程对于临床决策或说明目的可能有用，但可能会对统计评估产生负面影响。通常对于免疫组织化学数据的临界值没有标准化。在许多研究中，完全没有理由选择截止水平。因此，几乎无法比较不同出版物的结果。

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