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首页> 外文期刊>Journal of drug delivery science and technology >Passive delivery techniques for transcutaneous immunization
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Passive delivery techniques for transcutaneous immunization

机译：被动递送技术用于经皮免疫

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摘要

Transcutaneous immunization is a potential and attractive alternative to conventional vaccination, due to the unique immunological characteristics of skin. Despite several studies on transcutaneous immunization using novel techniques, it has not been exploited to its full potential because of the complex barrier property of stratum corneum. There are several successful reports on transcutaneous delivery of vaccines by using different novel physical devices, but considering the potential problem of vaccination in developing countries, these novel physical techniques might not solve the problem of effective vaccination because of economic issues. Therefore, the research in the field of passive transcutaneous delivery of these vaccines could be more attractive and cost effective. This review mainly focuses on mechanism and adjuvants frequently used in transcutaneous immunization and several other passive techniques which have been investigated so far in the field of transcutaneous vaccine delivery.
机译：由于皮肤独特的免疫学特性，经皮免疫是常规疫苗的一种潜在且有吸引力的替代方法。尽管使用新技术对经皮免疫进行了几项研究，但由于角质层具有复杂的屏障特性，因此尚未充分发挥其潜力。关于使用不同的新型物理设备经皮递送疫苗的成功报道，但考虑到发展中国家的疫苗接种潜在问题，由于经济问题，这些新型物理技术可能无法解决有效疫苗接种的问题。因此，在这些疫苗的被动经皮递送领域中的研究可能更有吸引力并且更具成本效益。这篇综述主要集中在经皮免疫中常用的机制和佐剂，以及迄今为止在经皮疫苗递送领域中已经研究的其他几种被动技术。

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