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首页> 外文期刊>Journal of cutaneous pathology >Evaluation of follicular T-helper cells in primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma and dermatitis
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Evaluation of follicular T-helper cells in primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma and dermatitis

机译：评价原发性皮肤CD4 +中小多形性T细胞淋巴瘤和皮炎中的滤泡性T辅助细胞

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Background: CD4+ small/medium-sized pleomorphic T-cell lymphoma (SMPTCL) is a controversial primary cutaneous lymphoma, in which the candidate neoplastic cells express a follicular T-helper phenotype. We describe 16 cases of SMPTCL and compare expression of PD-1, CXCL-13 and ICOS in these tumors with 40 dermatitis cases. Methods: Histopathologic examination and immunocytochemistry were performed for 16 tumors and 40 assorted dermatitis cases. Results: All but one patient presented with solitary lesions. Each biopsy revealed a dense nodular non-epitheliotropic infiltrate of atypical T-cells. Neoplastic cells were CD3+/CD4+/CD8(-)/CD30(-). Cutaneous recurrence occurred in one patient over a median follow up of 8 months (range 5-36). All tumors widely expressed PD-1 and ICOS to a lesser extent. CXCL-13 stained much fewer cells. Of the dermatitis cases, PD-1 (most numerous) and ICOS labeled lymphoid cells in all cases, albeit fewer than in the tumors, and CXCL-13 was negative in 32. A rosette pattern of PD-1 expression was identified in all the SMPTCL cases but not in dermatitis. Conclusions: There remains uncertainty about the appropriate nosological status of SMPTCL, which some authors consider to be a pseudolymphoma. However, this study suggests a significant difference in the prevalence and pattern of follicular T-helper cell markers between this tumor and lymphoid proliferations known to be reactive.
机译：背景：CD4 +中小型多形性T细胞淋巴瘤（SMPTCL）是引起争议的原发性皮肤淋巴瘤，其中候选肿瘤细胞表达滤泡性T辅助表型。我们描述了16例SMPTCL，并比较了这些肿瘤与40例皮炎中PD-1，CXCL-13和ICOS的表达。方法：对16例肿瘤和40例各种皮炎进行了组织病理学检查和免疫细胞化学检查。结果：除一名患者外，所有患者均出现孤立性病变。每次活检均显示非典型T细胞呈浓密结节性非上皮性浸润。肿瘤细胞是CD3 + / CD4 + / CD8（-）/ CD30（-）。在中位随访8个月（范围5-36）中，一名患者发生皮肤复发。所有肿瘤在较小程度上广泛表达PD-1和ICOS。 CXCL-13染色的细胞少得多。在所有皮炎病例中，PD-1（最多）和ICOS标记的淋巴样细胞均在所有病例中，尽管少于肿瘤中的数目，并且CXCL-13在32例中呈阴性。 SMPTCL病例但不是皮炎。结论：关于SMPTCL的适当的病原学状态仍存在不确定性，一些作者认为这是假淋巴瘤。但是，这项研究表明该肿瘤与已知为反应性的淋巴样增生之间的滤泡性T辅助细胞标志物的发生率和模式有显着差异。

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