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首页> 外文期刊>Journal of drug research. >The Protective Effects of Ginseng Extract Against Carbon Tetrachloride-Induced Liver Cirrhosis
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The Protective Effects of Ginseng Extract Against Carbon Tetrachloride-Induced Liver Cirrhosis

机译：人参提取物对四氯化碳诱导的肝硬化的保护作用

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Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue. Panax ginseng is believed to be a general tonic or adaptogen for promoting longevity and as medicinal herb due to their perceived potential health benefits. This work aimed studying the possible protective action of ginseng extract on liver cirrhosis induced by ССЦ. To this end, 60 healthy male Sprague Dawley rats were divided into 6 groups (n=10 each): (i) normal control group, (ii) CC14 (4ml/kg, i.p., twice a week for 12 weeks, (iii) vitamin E (100 mg/kg daily for 12 weeks), (iv) ginseng extract (0.7 g/kg, p.o., daily dose for 12 weeks), (v) ССЦ+vitamin E-treated groups, and (vi) CCl4+ginseng-treated groups. Twenty four hours later, blood and liver samples were collected for determination of prothrombm time, tumor necrosis factor a (TNF-a), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, total protein, total bilirubin, liver content of reduced glutathione (GSH) and malondialdehyde (MDA) and relative liver weight Histopathological and histochemical examination of rats' livers for glycogen and DNA components were also performed. Results showed that CC14 administration induced significant increases in prothrombin time, TNF-a, ALT, AST, ALP, total bilirubin, MDA, relative liver weight and significant decrease levels of serum albumin, total protein and GSH as well as depletion of liver glycogen and fragmented hepatocytes DNA. Co-administration of ginseng extract with ССЦ significantly increased level of serum albumin, total protein, GSH and reduced level of serum ALT, AST, ALP, TNF-a, prothrombm time and relative liver weight compared to CCl4-treated group. Histopathological examination of liver tissue showed that ginseng extract decreased the cellular changes and cirrhosis induced by CC14 alone. Meanwhile, со-administration of ginseng extract with CC14 significantly increased liver glycogen and normalized DNA components.These data suggested that ginseng extract induces some protection against liver cirrhosis induced by CC14.
机译：肝硬化是慢性肝病的结果，其特征在于肝组织被纤维化瘢痕组织替代。人参被认为是促进长寿的通用补品或适应原，由于它们具有潜在的健康益处，因此可以作为药草。这项工作旨在研究人参提取物对ССЦ所致肝硬化的可能的保护作用。为此，将60只健康的Sprague Dawley雄性大鼠分为6组（每组n = 10）：（i）正常对照组，（ii）CC14（4ml / kg，腹腔注射，每周两次，连续12周，（iii）维生素E（每天100 mg / kg，持续12周），（iv）人参提取物（0.7 g / kg，口服，每天剂量，持续12周），（v）ССЦ+维生素E治疗组和（vi）CCl4 +人参治疗组24小时后，收集血液和肝脏样品，以测定凝血酶原时间，肿瘤坏死因子a（TNF-a），丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），碱性磷酸酶（ALP），还进行了大鼠白蛋白，总蛋白，总胆红素，还原型谷胱甘肽（GSH）和丙二醛（MDA）的肝脏含量以及相对肝脏重量的肝脏组织病理学和组织化学检查，结果显示糖原和DNA成分明显增加凝血酶原时间，TNF-α，ALT，AST，ALP，总胆红素，MDA，相对肝脏重量和信号导致血清白蛋白，总蛋白和谷胱甘肽水平降低，肝糖原和肝细胞碎片DNA减少。与CCl4处理组相比，人参提取物与ССЦ的共同给药显着增加了血清白蛋白，总蛋白，GSH的水平，并降低了血清ALT，AST，ALP，TNF-α，血栓形成时间和相对肝脏重量。肝组织的组织病理学检查显示，人参提取物减少了仅由CC14引起的细胞变化和肝硬化。同时，人参提取物与CC14的联合给药显着增加了肝糖原和DNA成分的标准化。这些数据表明，人参提取物对CC14诱导的肝硬化具有一定的保护作用。

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