Using grid techniques for drug target identification.

Jiang Z; Lu F; Zhang J

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Using grid techniques for drug target identification.

机译：使用网格技术识别药物目标。

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The completion of the sequencing of the human genome has opened an unprecedented opportunity in the discovery of novel drug targets for disease therapy. However, one of the major challenges facing the drug discovery community is the expanding of data and the need of large-scale computational power in a collaborative environment. Grid techniques can present an architectural framework that aims to provide access to heterogeneous resources in a secure, reliable and scalable manner across various administrative boundaries for drug discovery, which has been a promising strategy for solving large-scale problems in modern pharmaceutical R&D. In this review, we discuss the current applications of Grid technology in drug target protein identification process; and an overview of drug target discovery system architecture, focusing in particular on the data manager service system architecture is also proposed.

机译：人类基因组测序的完成为发现用于疾病治疗的新型药物靶标提供了前所未有的机会。但是，药物发现社区面临的主要挑战之一是数据的扩展以及在协作环境中对大规模计算能力的需求。网格技术可以提供一种体系结构框架，该框架旨在以安全，可靠和可扩展的方式跨各种管理边界提供对异构资源的访问以进行药物发现，这已成为解决现代药物研发中大规模问题的一种有前途的策略。在这篇综述中，我们讨论了网格技术在药物靶蛋白鉴定过程中的当前应用;还提出了药物靶标发现系统架构的概述，尤其是数据管理器服务系统架构。

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《Journal of drug targeting》 |2006年第9期|共9页
作者
Jiang Z; Lu F; Zhang J;
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正文语种 eng
中图分类药学;
关键词
Methodology; drug discovery; overview; novel; strategy;

机译：方法论;药物发现;概述;新颖;策略;

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专利

1. Using grid techniques for drug target identification. [J] . Jiang Z, Lu F, Zhang J Journal of drug targeting . 2006,第9期

机译：使用网格技术识别药物目标。
2. Recent advances and method development for drug target identification. [J] . Chan JN, Nislow C, Emili A Trends in pharmacological sciences . 2010,第2期

机译：用于药物靶标鉴定的最新进展和方法开发。
3. Yeast genomics and drug target identification. [J] . Bharucha N, Kumar A Combinatorial chemistry & high throughput screening . 2007,第8期

机译：酵母基因组学和药物靶标鉴定。
4. Drug target interaction predictions using PU- Leaming under different experimental setting for four formulations namely known drug target pair prediction, drug prediction, target prediction and unknown drug target pair prediction [C] . Hetal Rahul Rajpura, Alioune Ngom IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology . 2018

机译：使用PU-Leaming在不同实验设置下针对四种制剂的药物靶相互作用预测，即已知药物靶对预测，药物预测，靶预测和未知药物靶对预测
5. Development of two-dimensional parametric radar signal modeling and estimation techniques with application to target identification. [D] . Sacchini, Joseph John. 1992

机译：二维参数化雷达信号建模和估计技术的发展及其在目标识别中的应用。
6. Endocarditis of native aortic and mitral valves due to Corynebacterium accolens: report of a case and application of phenotypic and genotypic techniques for identification. [O] . G Claeys, H Vanhouteghem, P Riegel, 1996

机译：Accorens accolens引起的天然主动脉和二尖瓣内膜炎：表型和基因型技术鉴定的病例报告和应用。
7. A comparison of the K-Pulse and E-Pulse techniques for aspect independent radar target identification. [O] . Simon Martin S. 1989

机译：比较K脉冲和E脉冲技术以进行与方面无关的雷达目标识别。

Using grid techniques for drug target identification.

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