The 'fate' of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system

Tosi Giovanni; Musumeci Teresa; Ruozi Barbara; Carbone Claudia; Belletti Daniela; Pignatello Rosario; Vandelli Maria Angela; Puglisi Giovanni

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The 'fate' of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system

机译：用于脑部递送和靶向的聚合物纳米颗粒和脂质纳米颗粒的“命运”：血脑屏障穿越和转运至中枢神经系统的策略和机制

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Drug delivery to the brain represents one of the most important challenges in the field of nanomedicine, as the study and planning of nanocarriers able to cross the blood brain barrier are topics at the cutting edge of technology and innovation. In this review, we analyze the interventions and progresses in the field, by analyzing the choice of the polymer, of the ligands and the main relevant in vivo and in vitro experiments. A critical overview of these aspects will help in better understanding the status of nanomedicine in the application to central nervous system pathologies along with the future directions. (C) 2015 Elsevier B.V. All rights reserved.

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《Journal of drug delivery science and technology》 |2016年第2期|共11页
作者
Tosi Giovanni; Musumeci Teresa; Ruozi Barbara; Carbone Claudia; Belletti Daniela; Pignatello Rosario; Vandelli Maria Angela; Puglisi Giovanni;
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正文语种 eng
中图分类药学;
关键词
Nanomedicine; Polymeric nanoparticles; Solid lipid nanoparticles; Brain; Blood brain barrier; Central nervous system; Brain tumors;

机译：纳米药物;聚合物纳米颗粒;固体脂质纳米颗粒;脑;血脑屏障;中枢神经系统;脑肿瘤;

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1. The "fate" of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system [J] . Tosi Giovanni, Musumeci Teresa, Ruozi Barbara, Journal of drug delivery science and technology . 2016,第Pta2期

机译：用于脑部递送和靶向的聚合物纳米颗粒和脂质纳米颗粒的“命运”：血脑屏障穿越和转运至中枢神经系统的策略和机制
2. Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases [J] . Nur Izzati Mansor, Norshariza Nordin, Farahidah Mohamed, Current drug delivery . 2019,第8期

机译：穿越血脑屏障：治疗中枢神经系统疾病的药物交付策略综述
3. Nanoparticle crossing of blood-brain barrier: a road to new therapeutic approaches to central nervous system diseases [J] . Cena Valentin, Jativa Pablo Nanomedicine . 2018,第13期

机译：血型脑屏障的纳米粒子交叉：新治疗方法对中枢神经系统疾病的道路
4. Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system [C] . Nathan McDannold, Yongzhi Zhang, Chanikarn Power, Conference on Micro- and Nanotechnology Sensors, Systems, and Applications . 2015

机译：超声介导的血脑屏障破坏，用于中枢神经系统的靶向药物输送
5. Targeted brain delivery of novel nanoparticles via the blood-brain barrier thiamine transporter. [D] . Lockman, Paul Richard. 2003

机译：通过血脑屏障硫胺素转运蛋白的靶向脑部递送。
6. Systemic Delivery of Blood-Brain Barrier Targeted Polymeric Nanoparticles Enhances Delivery to Brain Tissue [O] . Jennifer K. Saucier-Sawyer, Yang Deng, Young-Eun Seo, -1

机译：血脑屏障靶向聚合物纳米颗粒的系统性输送增强了对脑组织的输送。
7. Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease [O] . 2008

机译：鼻内给药绕过血脑屏障，将治疗剂靶向中枢神经系统并治疗神经退行性疾病
8. Central Nervous Ionic Homeostasis (Ionic Regulation by the Insect Blood-Brain Barrier) [R] . Treherne, J. E. 1980

机译：中枢神经离子稳态（昆虫血脑屏障的离子调节）

The 'fate' of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system

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