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首页> 外文期刊>Journal of drug delivery science and technology >Erodible drug delivery systems for time-controlled release into the gastrointestinal tract
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Erodible drug delivery systems for time-controlled release into the gastrointestinal tract

机译：可侵蚀的药物输送系统，可控制时间释放到胃肠道

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摘要

In oral delivery, lag phases of programmable duration that precede drug release may be advantageous in a number of instances, e.g. to meet chronotherapeutic needs or pursue colonic delivery. Systems that give rise to characteristic lag phases in their release profiles, i.e. intended for time-controlled release, are generally composed of a drug-containing core and a functional polymeric barrier. According to the nature of the polymer, the latter may delay the onset of drug release by acting as a rupturable, permeable or erodible boundary layer. Erodible systems are mostly based on water swellable polymers, such as hydrophilic cellulose ethers, and the release of the incorporated drug is deferred through the progressive hydration and erosion of the polymeric barrier upon contact with aqueous fluids. The extent of delay depends on the employed polymer, particularly on its viscosity grade, and on the thickness of the layer applied. The manufacturing technique may also have an impact on the performance of such systems. Double-compression and spray-coating have mainly been used, resulting in differing technical issues and release outcomes. In this article, an update on delivery systems based on erodible polymer barriers (coatings, shells) for time-controlled release is presented. (C) 2015 Elsevier B.V. All rights reserved.
机译：在口服给药中，在许多情况下，例如在药物释放之前，在药物释放之前的可编程持续时间的滞后阶段可能是有利的。以满足计时治疗的需要或追求结肠分娩。在其释放曲线中产生特征性滞后阶段的系统，即用于时间控制释放的系统，通常由包含药物的核心和功能性聚合物屏障组成。根据聚合物的性质，后者可以充当可破裂，可渗透或易蚀的边界层，从而延迟药物释放的开始。可腐蚀的系统主要基于水溶胀性聚合物（例如亲水性纤维素醚），并且与水性流体接触后，聚合物屏障的逐步水化和侵蚀会延迟掺入药物的释放。延迟的程度取决于所使用的聚合物，特别是取决于其粘度等级，以及取决于所施加的层的厚度。制造技术也可能对此类系统的性能产生影响。主要使用双重压缩和喷涂，导致不同的技术问题和释放结果。在本文中，将介绍基于时间控制释放的基于易蚀聚合物屏障（涂层，外壳）的输送系统的更新。 （C）2015 Elsevier B.V.保留所有权利。

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