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首页> 外文期刊>Clinical chemistry and laboratory medicine: CCLM >Reference intervals for 24 laboratory parameters determined in 24-hour urine collections
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Reference intervals for 24 laboratory parameters determined in 24-hour urine collections

机译：24小时尿液收集中确定的24个实验室参数的参考间隔

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Background: Reference intervals for many laboratory parameters determined in 24-h urine collections are either not publicly available or based on small numbers, not sex specific or not from a representative sample. Methods: Osmolality and concentrations or enzymatic activities of sodium, potassium, chloride, glucose, creatinine, citrate, cortisol, pancreatic a-amylase, total protein, albumin, transferrin, immunoglobulin G, alpha(1-) microglobulin, alpha(2)-macroglobulin, as well as porphyrins and their precursors (delta-aminolevulinic acid and porphobilinogen) were determined in 241 24-h urine samples of a population-based cohort of asymptomatic adults (121 men and 120 women). For 16 of these 24 parameters creatinine-normalized ratios were calculated based on 24-h urine creatinine. The reference intervals for these parameters were calculated according to the CLSI C28-A3 statistical guidelines. Results: By contrast to most published reference intervals, which do not stratify for sex, reference intervals of 12 of 24 laboratory parameters in 24-h urine collections and of eight of 16 parameters as creatinine-normalized ratios differed significantly between men and women. For six parameters calculated as 24-h urine excretion and four parameters calculated as creatinine-normalized ratios no reference intervals had been published before. For some parameters we found significant and relevant deviations from previously reported reference intervals, most notably for 24-h urine cortisol in women. Ten 24-h urine parameters showed weak or moderate sex-specific correlations with age. Conclusions: By applying up-to-date analytical methods and clinical chemistry analyzers to 24-h urine collections from a large population-based cohort we provide as yet the most comprehensive set of sex-specific reference intervals calculated according to CLSI guidelines for parameters determined in 24-h urine collections.
机译：背景：24小时尿液收集中确定的许多实验室参数的参考间隔不是公开可用的，还是基于少量，非性别特异性或非代表性样品的参考间隔。方法：渗透压和钠，钾，氯，葡萄糖，肌酐，柠檬酸盐，皮质醇，胰α-淀粉酶，总蛋白，白蛋白，转铁蛋白，免疫球蛋白G，α（1-）微球蛋白，α（2）-的浓度或酶活性在人群无症状的成年人（121名男性和120名女性）的241个24小时尿液样本中确定了巨球蛋白以及卟啉及其前体（δ-氨基乙酰丙酸和胆色素原）。对于这24个参数中的16个，基于24小时尿肌酐计算肌酐归一化比率。这些参数的参考间隔是根据CLSI C28-A3统计准则计算得出的。结果：与大多数公开发表的参考间隔（未按性别分层）相比，在24小时尿液收集中，有24个实验室参数中的12个和16个参数中的8个的参考间隔，因为肌酐标准化比率在男女之间有显着差异。对于以24小时尿液排泄计算的六个参数和以肌酐归一化比率计算的四个参数，之前没有公布参考间隔。对于某些参数，我们发现与先前报告的参考间隔存在明显和相关的偏差，最明显的是女性的24小时尿皮质醇。十个24小时尿液参数显示与年龄的性别相关性较弱或中等。结论：通过将最新的分析方法和临床化学分析仪应用于来自大型人群的24小时尿液收集，我们提供了根据CLSI指南确定的参数最全面的性别特异性参考区间集在24小时内收集尿液。

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