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Clinical and antimicrobial evaluation of a mouthwash and toothpaste for xerostomia: a randomized, double-blind, crossover study.

机译:口腔干燥剂和牙膏对口腔干燥症的临床和抗菌评估:一项随机,双盲,交叉研究。

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OBJECTIVES: Specific toothpaste and mouthwash for xerostomia based on triclosan, fluoride, and mineral salts were studied in order to evaluate their efficacy in improving the quality of life as well as their in vitro antimicrobial action. MATERIALS AND METHODS: 30 patients with dry mouth and hyposalivation confirmed by sialometry were included in a randomized, double-blind, crossover study, during two weeks for each experimental phase. Dryness and oral comfort, difficulty in speaking, chewing, swallowing and using dental prostheses, as well as taste and sleep disorders were evaluated. Values of minimal biocidal and minimal inhibitory concentrations of both products against microorganisms that often cause oral disorders in these patients were determined and compared. RESULTS: The use of the mouthwash and toothpaste studied improved the dry mouth symptoms, whilst no significant differences when compared with the salivary enzyme substitutes were observed. The test products showed, in general, a higher biocidal and inhibitory action than the control products, with particularly noteworthy action against cariogenic bacteria. CONCLUSIONS: The use of a toothpaste and mouthwash based on triclosan, fluoride, gingival revitalizers and mineral salts, improves the quality of life of patients suffering xerostomia.
机译:目的:研究了基于三氯生,氟化物和无机盐的口腔干燥症专用牙膏和漱口水,以评估其改善生活质量的功效以及体外抗菌作用。材料与方法:30例经口气计量法确诊的口干和唾液分泌不足的患者,在每个实验阶段的两周内纳入一项随机,双盲,交叉研究。评估干燥度和口腔舒适度,说话,咀嚼,吞咽和使用假牙的困难程度,以及味觉和睡眠障碍。确定并比较了两种产品对这些患者中经常引起口腔疾病的微生物的最小杀生物浓度和最小抑菌浓度。结果:研究的漱口水和牙膏的使用改善了口干症状,但与唾液酶替代品相比没有显着差异。一般而言,测试产品显示出比对照产品更高的杀生物和抑制作用,对生龋细菌的作用尤为显着。结论:使用基于三氯生,氟化物,牙龈赋活剂和矿物质盐的牙膏和漱口水可改善口干症患者的生活质量。

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